{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:27:06Z","timestamp":1789000026278,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"\n Background:<\/jats:title>\n The condition of the hair is closely related to the nutritional state. Normal supply, uptake, and transport of nutrients are of fundamental importance in tissues with a high biosynthetic activity such as the hair follicle.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The objective of the study was to evaluate the efficacy of a nutritional-based induction and maintenance treatment for telogen effluvium formulated with a combination of hydrolyzed collagen, amino acids, vitamins, and minerals.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods:<\/jats:title>\n The clinical studies were conducted with each nutritional treatment individually, and both in sequential combination. Anagen\/telogen ratio, hair density, and tolerability of treatment were assessed at baseline, 4 weeks of induction therapy, and another 12 weeks of maintenance treatment. Trichogram results showed a significant improvement of the anagen\/telogen ratio between baseline and final visit at 16 weeks, with an increase of hair in anagen and a reduction of hair in telogen. Furthermore, a significant increase was observed in hair density. The effect size of the combination treatment was higher than that of each of the two products used separately as monotherapy.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The study results provide a proof of concept for targeted nutritional supplementation for the treatment of telogen effluvium, with a special emphasis on the role of collagen, besides specific amino acids, vitamins, and minerals.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijt.ijt_57_21","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T06:16:34Z","timestamp":1649052994000},"page":"49-54","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Targeted Nutritional Supplementation for Telogen Effluvium"],"prefix":"10.4103","volume":"14","author":[{"given":"Eva Maria","family":"Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Floriach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Moreno-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Michel","family":"Tr\u00fceb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-2-20240903","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4103\/0378-6323.116731","article-title":"Telogen effluvium","volume":"79","author":"Grover","year":"2013","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R3-2-20240903","first-page":"40","article-title":"The trichogram. Structural and functional basis, performance, and interpretation","volume":"4","author":"Braun-Falco","year":"1985","journal-title":"Sem Dermatol"},{"key":"R4-2-20240903","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/archderm.1961.01580080005001","article-title":"Pathologic dynamics of human hair loss, I: Telogen effluvium","volume":"83","author":"Kligman","year":"1961","journal-title":"Arch Dermatol"},{"key":"R5-2-20240903","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1365-2230.2002.01080.x","article-title":"Telogen effluvium","volume":"27","author":"Harrison","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"R6-2-20240903","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/archderm.1993.01680240096017","article-title":"Telogen effluvium. New concepts and review","volume":"129","author":"Headington","year":"1993","journal-title":"Arch Dermatol"},{"key":"R7-2-20240903","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/sj.jid.5701147","article-title":"Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression","volume":"128","author":"Bahta","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R8-2-20240903","doi-asserted-by":"crossref","first-page":"aad4395","DOI":"10.1126\/science.aad4395","article-title":"Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis","volume":"351","author":"Matsumura","year":"2016","journal-title":"Science"},{"key":"R9-2-20240903","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1093\/jn\/129.10.1891","article-title":"Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57\/BL)","volume":"129","author":"Oesser","year":"1999","journal-title":"J Nutr"},{"key":"R10-2-20240903","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1021\/jf050206p","article-title":"Identification of food-derived collagen peptides in human blood after oral ingestion of gelatine hydrolysates","volume":"53","author":"Iwai","year":"2005","journal-title":"J Agric Food Chem"},{"key":"R11-2-20240903","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3177\/jnsv.52.211","article-title":"Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis","volume":"52","author":"Matsuda","year":"2006","journal-title":"J Nutr Sci Vitaminol (Tokyo"},{"key":"R12-2-20240903","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1073\/pnas.75.2.871","article-title":"Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides","volume":"75","author":"Postlethwaite","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-2-20240903","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/jf802785h","article-title":"Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin","volume":"57","author":"Shigemura","year":"2009","journal-title":"J Agric Food Chem"},{"key":"R14-2-20240903","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1001\/archinte.158.20.2187","article-title":"Battling quackery: Attitudes about micronutrient supplements in American academic medicine","volume":"158","author":"Goodwin","year":"1998","journal-title":"Arch Intern Med"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_57_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:54Z","timestamp":1787166714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_57_21"}},"subtitle":["Multicenter Study on Efficacy of a Hydrolyzed Collagen, Vitamin-, and Mineral-Based Induction and Maintenance Treatment"],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_57_21","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}