{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:55Z","timestamp":1787169715010,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Alopecia areata (AA) is an organ-specific autoimmune disease which affects hair follicles. It usually presents as a transient patchy hair loss, but it can sometimes progress into more severe forms such as AA totalis or AA universalis (AAU). Different autoimmune diseases, as well as autoimmune polyglandular syndromes (APS), have been associated with AA, especially with Type I and Type II APS. Herein, we describe the case of a 16-year-old boy with a severe form of AAU and early onset of adult APS, Type III C. As far as we are aware, this combination of AAU, Hashimoto thyroiditis, and Type I diabetes in a teenager has not been previously described in the literature. Furthermore, the early onset of AAU followed by a premature debut of adult APS Type III is again unique, which is why we report this case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_77_20","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T06:16:34Z","timestamp":1649052994000},"page":"62-64","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Alopecia Areata Universalis in the Onset of Autoimmune Polyendocrine Syndrome Type III C"],"prefix":"10.4103","volume":"14","author":[{"given":"Nicoleta","family":"Neagu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviu Horia","family":"Morariu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Grama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240903","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5021\/ad.2017.29.5.565","article-title":"Factors associated with severity of alopecia areata","volume":"29","author":"You","year":"2017","journal-title":"Ann Dermatol"},{"key":"R2-5-20240903","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jdv.13959","article-title":"Alopecia areata totalis and universalis: A multicenter review of 132 patients in Spain","volume":"31","author":"Va\u00f1\u00f3-Galv\u00e1n","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R3-5-20240903","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.crohns.2012.05.009","article-title":"Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease","volume":"7","author":"Protic","year":"2013","journal-title":"J Crohns Colitis"},{"key":"R4-5-20240903","first-page":"74","article-title":"Autoimmune polyglandular syndrome type 2 with alopecia universalis and hypoparathyroidism","volume":"63","author":"Dave","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"R5-5-20240903","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0974-7753.125624","article-title":"Alopecia universalis in polyglandular autoimmune syndrome type I","volume":"5","author":"Sardesai","year":"2013","journal-title":"Int J Trichology"},{"key":"R6-5-20240903","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s40618-017-0740-9","article-title":"Polyglandular autoimmune syndromes","volume":"41","author":"Kahaly","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"R7-5-20240903","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/ijt.ijt_102_17","article-title":"Dermoscopic findings in 126 patients with alopecia areata: A cross-sectional study","volume":"10","author":"Mahmoudi","year":"2018","journal-title":"Int J Trichology"},{"key":"R8-5-20240903","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2230.2006.02171.x","article-title":"Vitiligo associated with other autoimmune diseases: Polyglandular autoimmune syndrome types 3B+C and 4","volume":"31","author":"Amerio","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"R9-5-20240903","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4158\/EP.15.2.138","article-title":"Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: An unusual case of autoimmune polyglandular syndrome type 3","volume":"15","author":"Sheehan","year":"2009","journal-title":"Endocr Pract"},{"key":"R10-5-20240903","doi-asserted-by":"crossref","first-page":"bcr1020092335","DOI":"10.1136\/bcr.10.2009.2335","article-title":"Alopecia universalis, hypothyroidism and pituitary hyperplasia: Polyglandular autoimmune syndrome III in a patient in remission from treated Hodgkin lymphoma","volume":"2010","author":"Quintyne","year":"2010","journal-title":"BMJ Case Rep"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_77_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:12:23Z","timestamp":1787166743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_77_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_77_20","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}