{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:48:43Z","timestamp":1786718923155,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Trichol"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/ijt.ijt_80_18","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T04:21:40Z","timestamp":1550031700000},"page":"26","source":"Crossref","is-referenced-by-count":39,"title":["Serum interleukin-15 is a marker of alopecia areata severity"],"prefix":"10.4103","volume":"11","author":[{"given":"RehabMohammed","family":"Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AdelAli","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AsmaaAdel","family":"El Fallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EsraaTaha","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0974-7753.252222-1","first-page":"1077","volume-title":"Evidence that the bulge region is a site of relative immune privilege in human hair follicles","author":"Meyer","year":"2008","journal-title":"Br J Dermatol"},{"key":"key-10.4103\/0974-7753.252222-2","first-page":"1617","volume-title":"Identification of autoantigen epitopes in Alopecia areata","author":"Wang","year":"2016","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/0974-7753.252222-3","unstructured":"de Berker D, Higgins CA, Jahoda C, Christiano AM. Biology of hair and nails. In: Jean B, Jorizzo JL, Schaffer JV. Dermatology. Philadelphia: Elsevier Saunders; 2012. p. 1081-99."},{"key":"key-10.4103\/0974-7753.252222-4","first-page":"575","volume-title":"NKG2D receptor and its ligands in host defense","author":"Lanier","year":"2015","journal-title":"Cancer Immunol Res"},{"key":"key-10.4103\/0974-7753.252222-5","first-page":"563","volume-title":"Alopecia areata: An update","author":"Seetharam","year":"2013","journal-title":"Indian J Dermatol Venereol Leprol","ISSN":"https:\/\/id.crossref.org\/issn\/0378-6323","issn-type":"print"},{"key":"key-10.4103\/0974-7753.252222-6","first-page":"51","volume-title":"Alopecia areata: Review of epidemiology, clinical features, pathogenesis, and new treatment options","author":"Darwin","year":"2018","journal-title":"Int J Trichology"},{"key":"key-10.4103\/0974-7753.252222-7","first-page":"S12","volume-title":"Hair follicle immune privilege revisited: The key to alopecia areata management","author":"Paus","year":"2018","journal-title":"J Investig Dermatol Symp Proc"},{"key":"key-10.4103\/0974-7753.252222-8","first-page":"247","volume-title":"The role of interleukin-15 in inflammation and immune responses to infection: Implications for its therapeutic use","author":"Perera","year":"2012","journal-title":"Microbes Infect"},{"key":"key-10.4103\/0974-7753.252222-9","first-page":"1043","volume-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","author":"Xing","year":"2014","journal-title":"Nat Med"},{"key":"key-10.4103\/0974-7753.252222-10","first-page":"440","volume-title":"Alopecia areata investigational assessment guidelines \u2013 Part II.National alopecia areata foundation","author":"Olsen","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"key-10.4103\/0974-7753.252222-11","first-page":"121","volume-title":"Alopecia areata","author":"Wasserman","year":"2007","journal-title":"Int J Dermatol"},{"key":"key-10.4103\/0974-7753.252222-12","first-page":"9","volume-title":"Toward the clonotype analysis of alopecia areata-specific, intralesional human CD8+T lymphocytes","author":"Bertolini","year":"2015","journal-title":"J Investig Dermatol Symp Proc"},{"key":"key-10.4103\/0974-7753.252222-13","first-page":"14","volume-title":"Interleukin 15: Biology and relevance to human disease","author":"Fehniger","year":"2001","journal-title":"Blood"},{"key":"key-10.4103\/0974-7753.252222-14","first-page":"189","volume-title":"Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis","author":"McInnes","year":"1997","journal-title":"Nat Med"},{"key":"key-10.4103\/0974-7753.252222-15","first-page":"876","volume-title":"Serum interleukin-15 is elevated in systemic lupus erythematosus","author":"Aringer","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"key-10.4103\/0974-7753.252222-16","first-page":"917","volume-title":"Increased IL-15 production of muscle cells in polymyositis and dermatomyositis","author":"Sugiura","year":"2002","journal-title":"Int Immunol"},{"key":"key-10.4103\/0974-7753.252222-17","first-page":"359","volume-title":"A role for th1 and th2 cells in the immunopathogenesis of atopic dermatitis","author":"Grewe","year":"1998","journal-title":"Immunol Today"},{"key":"key-10.4103\/0974-7753.252222-18","first-page":"2240","volume-title":"Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis?","author":"R\u00fcckert","year":"2000","journal-title":"J Immunol"},{"key":"key-10.4103\/0974-7753.252222-19","first-page":"336","volume-title":"Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?","author":"Lesiak","year":"2016","journal-title":"Postepy Dermatol Alergol"},{"key":"key-10.4103\/0974-7753.252222-20","first-page":"1180","volume-title":"From palliation to targeted therapy in myelofibrosis","author":"Vannucchi","year":"2010","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0974-7753.252222-21","first-page":"236","volume-title":"Immune privilege collapse and alopecia development: Is stress a factor","author":"Azzawi","year":"2018","journal-title":"Skin Appendage Disord"},{"key":"key-10.4103\/0974-7753.252222-22","first-page":"409","volume-title":"Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy","author":"Barahmani","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"key-10.4103\/0974-7753.252222-23","first-page":"323","volume-title":"Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis","author":"Jujo","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"key-10.4103\/0974-7753.252222-24","first-page":"505","volume-title":"Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis","author":"Ong","year":"2002","journal-title":"J Immunol"},{"key":"key-10.4103\/0974-7753.252222-25","first-page":"1065","volume-title":"Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome\/Toxic epidermal necrolysis","author":"Su","year":"2017","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/0974-7753.252222-26","first-page":"142","volume-title":"Elevated serum levels of interleukin-15, interleukin-16, and human chorionic gonadotropin in women with preeclampsia","author":"El-Baradie","year":"2009","journal-title":"J Obstet Gynaecol Can"},{"key":"key-10.4103\/0974-7753.252222-27","first-page":"203","volume-title":"Serum interleukin-15 levels are associated with severity of pain in patients with knee osteoarthritis","author":"Sun","year":"2013","journal-title":"Dis Markers"},{"key":"key-10.4103\/0974-7753.252222-28","first-page":"174","volume-title":"Targeting the interleukin-15\/interleukin-15 receptor system in inflammatory autoimmune diseases","author":"Waldmann","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"key-10.4103\/0974-7753.252222-29","first-page":"5742","volume-title":"Targeting the IL-15 receptor with an antagonist IL-15 mutant\/Fc gamma2a protein blocks delayed-type hypersensitivity","author":"Kim","year":"1998","journal-title":"J Immunol"},{"key":"key-10.4103\/0974-7753.252222-30","first-page":"1571","volume-title":"Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model","author":"Villadsen","year":"2003","journal-title":"J Clin Invest"},{"key":"key-10.4103\/0974-7753.252222-31","first-page":"2686","volume-title":"Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study","author":"Baslund","year":"2005","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0974-7753.252222-32","doi-asserted-by":"crossref","unstructured":"Richmond JM, Strassner JP, Zapata L Jr., Garg M, Riding RL, Refat MA, et al. Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. Sci Transl Med 2018;10. pii: eaam7710.","DOI":"10.1126\/scitranslmed.aam7710"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:41:33Z","timestamp":1786714893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_80_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"alternative-id":["252222"],"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_80_18","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}