{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:36:28Z","timestamp":1789097788451,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Telogen effluvium (TE) is the most common hair loss. Vitamin D is related to hair and skin diseases due to its immunomodulatory and anti-inflammatory effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate Vitamin D serum level role in TE pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Forty females with TE were collected and twenty age- and sex-matched healthy individuals as controls. Serum 25(OH) Vitamin D level was estimated prior and 3 months after oral Vitamin D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum 25(OH) Vitamin D levels were significantly lower in TE patients than controls (13.31 \u00b1 5.8 ng\/ml vs. 33.61 \u00b1 8.16 ng\/ml) respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. The mean serum 25(OH) Vitamin D levels before treatment in acute TE was 12.31 \u00b1 6.88 ng\/ml, compared to 10.6 \u00b1 3.9 ng\/ml in chronic TE without a significant difference, (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.544). The mean serum 25(OH) Vitamin D levels in TE group after 3 months oral Vitamin D therapy were 38.4 \u00b1 15.22 ng\/ml with significant increase compared to pretreatment level, (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). However, without a significant difference between acute TE (45.4 \u00b1 9.22 ng\/ml) and chronic TE (42.1 \u00b1 10.6 ng\/ml), (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.711).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Oral Vitamin D has a promising effect in TE treatment, but the results need to be verified on a larger scale with evidence-based recommendation regarding the exact dose and treatment duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_92_22","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T17:00:31Z","timestamp":1720717231000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Oral Vitamin D Treatment in Patients with Telogen Effluvium: Clinical and Dermoscopic Evaluation"],"prefix":"10.4103","volume":"15","author":[{"given":"Rania Ahmed","family":"El-Tatawy","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Gheida","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Adbel Moamen","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Clinical Patholog, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"R1-20240903","first-page":"E01","article-title":"Telogen effluvium:A review","volume":"9","author":"Malkud","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000455882","article-title":"Intermittent chronic telogen effluvium","volume":"3","author":"Rebora","year":"2017","journal-title":"Skin Appendage Disord"},{"key":"R3-20240903","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/0378-6323.159928","article-title":"Vitamin D and skin diseases:A review","volume":"81","author":"Wadhwa","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R4-20240903","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000346698","article-title":"Serum ferritin and vitamin D in female hair loss:Do they play a role?","volume":"26","author":"Rasheed","year":"2013","journal-title":"Skin Pharmacol Physiol"},{"key":"R5-20240903","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/jocd.12224","article-title":"Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia","volume":"15","author":"Fawzi","year":"2016","journal-title":"J Cosmet Dermatol"},{"key":"R6-20240903","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/ced.12241","article-title":"Potential relationship between the canonical Wnt signalling pathway and expression of the vitamin D receptor in alopecia","volume":"39","author":"Lim","year":"2014","journal-title":"Clin Exp Dermatol"},{"key":"R7-20240903","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.abb.2011.10.002","article-title":"The hair cycle and vitamin D receptor","volume":"523","author":"Demay","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"R8-20240903","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.det.2012.08.007","article-title":"How to diagnose hair loss","volume":"31","author":"Jackson","year":"2013","journal-title":"Dermatol Clin"},{"key":"R9-20240903","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0974-7753.188965","article-title":"Serum vitamin D3 level in patients with female pattern hair loss","volume":"8","author":"Banihashemi","year":"2016","journal-title":"Int J Trichology"},{"key":"R10-20240903","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jaad.2016.10.002","article-title":"Hair pull test:Evidence-based update and revision of guidelines","volume":"76","author":"McDonald","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"R11-20240903","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0974-7753.130385","article-title":"Trichoscopy in alopecias:Diagnosis simplified","volume":"5","author":"Jain","year":"2013","journal-title":"Int J Trichology"},{"key":"R12-20240903","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1001\/archderm.1987.01660350088019","article-title":"Evaluation of oral minoxidil in the treatment of alopecia areata","volume":"123","author":"Fiedler-Weiss","year":"1987","journal-title":"Arch Dermatol"},{"key":"R13-20240903","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4103\/JCMRP.JCMRP_142_19","article-title":"Trichoscopic findings and quality-of-life assessment in Egyptian patients with noncicatricial alopecia","volume":"5","author":"Hofny","year":"2020","journal-title":"Curr Med Res Pract"},{"key":"R14-20240903","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5336\/dermato.2018-61736","article-title":"Evaluation of vitamin D levels in chronic telogen effluvium patients","volume":"28","author":"\u00c7\u0130","year":"2018","journal-title":"Turk Klin J Dermatol"},{"key":"R15-20240903","doi-asserted-by":"crossref","first-page":"190","DOI":"10.23736\/S0392-0488.19.06305-3","article-title":"Vitamin D in trichology:A comprehensive review of the role of vitamin D and its receptor in hair and scalp disorders","volume":"155","author":"Damiani","year":"2020","journal-title":"G Ital Dermatol Venereol"},{"key":"R16-20240903","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0974-7753.130385","article-title":"Trichoscopy in alopecias:Diagnosis simplified","volume":"5","author":"Jain","year":"2013","journal-title":"Int J Trichology"},{"key":"R17-20240903","first-page":"322","article-title":"Dermoscopic study of hair loss in females and its correlation with serum ferritin levels","volume":"29","author":"Shetty","year":"2019","journal-title":"J Pak Assoc Dermatol"},{"key":"R18-20240903","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/ijt.ijt_57_16","article-title":"Serum vitamin D3 levels and diffuse hair fall among the student population in South India:A case-control study","volume":"8","author":"Nayak","year":"2016","journal-title":"Int J Trichology"},{"key":"R19-20240903","first-page":"221","article-title":"Vitamin D level in female pattern hair loss with normal androgen level","volume":"32","author":"Hagag","year":"2019","journal-title":"Menoufia Med J"},{"key":"R20-20240903","doi-asserted-by":"crossref","first-page":"157","DOI":"10.9734\/jammr\/2021\/v33i1931091","article-title":"Evaluation of serum level of vitamin D in patients with female pattern hair loss thesis","volume":"33","author":"Sadoma","year":"2021","journal-title":"J Adv Med Med Res"},{"key":"R21-20240903","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1111\/jocd.14743","article-title":"Treatment with oral vitamin D alone, topical minoxidil, or combination of both in patients with female pattern hair loss:A comparative clinical and dermoscopic study","volume":"21","author":"Hassan","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"R22-20240903","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4172\/2167-0390.1000105","article-title":"Vitamin D concentrations are decreased in patients with alopecia areata","volume":"1","author":"Yilmaz","year":"2012","journal-title":"Vitam Trace Elem"},{"key":"R23-20240903","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/bjd.12980","article-title":"Vitamin D deficiency in alopecia areata","volume":"170","author":"Aksu","year":"2014","journal-title":"Br J Dermatol"},{"key":"R24-20240903","first-page":"367","article-title":"Association between vitamin D levels and alopecia areata","volume":"16","author":"Mahamid","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"R25-20240903","first-page":"112","article-title":"Telogen effluvium:Potential causes in Iraq","volume":"12","author":"Naif","year":"2016","journal-title":"Thi-Qar J Med"},{"key":"R26-20240903","first-page":"47","article-title":"Evaluation of serum zinc, iron profile and vitamin D in females of reproductive age group with diffuse hair loss:A case control study","volume":"2","author":"Surit","year":"2019","journal-title":"Ind J Clin Dermatol"},{"key":"R27-20240903","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.2001.81.1.449","article-title":"Controls of hair follicle cycling","volume":"81","author":"Stenn","year":"2001","journal-title":"Physiol Rev"},{"key":"R28-20240903","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jsbmb.2006.12.036","article-title":"Role of the vitamin D receptor in hair follicle biology","volume":"103","author":"Demay","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R29-20240903","doi-asserted-by":"crossref","first-page":"14653","DOI":"10.1073\/pnas.0507609102","article-title":"Hairless triggers reactivation of hair growth by promoting Wnt signaling","volume":"102","author":"Beaudoin","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R30-20240903","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1210\/jc.2018-02548","article-title":"Female pattern hair loss and androgen excess:A report from the multidisciplinary androgen excess and PCOS committee","volume":"104","author":"Carmina","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"R31-20240903","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4103\/2229-5178.190504","article-title":"Serum Vitamin D in patients with alopecia areata","volume":"7","author":"Bakry","year":"2016","journal-title":"Indian Dermatol Online J"},{"key":"R32-20240903","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4172\/2155-9554.1000431","article-title":"Etiological role of ferritin and vitamin D in patients with telogen effluvium","volume":"8","author":"Mohammad","year":"2017","journal-title":"J Clin Exp Dermatol Res"},{"key":"R33-20240903","first-page":"827","article-title":"The role of anemia and vitamin D levels in acute and chronic telogen effluvium","volume":"41","author":"Karada\u011f","year":"2011","journal-title":"Turk J Med Sci"},{"key":"R34-20240903","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/1523-1747.ep12460956","article-title":"Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice","volume":"96","author":"Slominski","year":"1991","journal-title":"J Invest Dermatol"},{"key":"R35-20240903","doi-asserted-by":"crossref","first-page":"E2653","DOI":"10.3390\/ijms18122653","article-title":"The role of vitamin D in non-scarring alopecia","volume":"18","author":"Gerkowicz","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R36-20240903","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3177\/jnsv.67.68","article-title":"Efficacy of oral vitamin D3 therapy in patients suffering from diffuse hair loss (telogen effluvium)","volume":"67","author":"Sattar","year":"2021","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"R37-20240903","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1210\/en.2002-220118","article-title":"Vitamin D3 analogs stimulate hair growth in nude mice","volume":"143","author":"Vegesna","year":"2002","journal-title":"Endocrinology"},{"key":"R38-20240903","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jare.2014.01.011","article-title":"Vitamin D and the skin:Focus on a complex relationship:A review","volume":"6","author":"Mostafa","year":"2015","journal-title":"J Adv Res"},{"key":"R39-20240903","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s11095-006-9105-3","article-title":"Protection against chemotherapy-induced alopecia","volume":"23","author":"Wang","year":"2006","journal-title":"Pharm Res"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_92_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:55:55Z","timestamp":1787838955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_92_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_92_22","relation":{},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2022-08-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}