{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:06:28Z","timestamp":1791511588882,"version":"4.3.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>Ichthyosis follicularis with alopecia and photophobia (IFAP) syndrome is a rare congenital genetic disorder characterized clinically by a triad of follicular ichthyosis, alopecia and photophobia. The genetic inheritance pattern in IFAP syndrome is said to be X-linked with mutations of the membrane-bound transcription factor peptidase, site 2 gene. Histopathology of the skin shows dilated hair follicles with keratin plugs extending above the surface of the skin. In this case report, we describe a 6-year-old girl with clinical features of IFAP along with palmoplantar keratoderma. Skin biopsy was done to confirm the diagnosis after which she was started on acitretin (10 mg per day). Good improvement in cutaneous features was observed after 1 month.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_9_22","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:30:23Z","timestamp":1678689023000},"page":"213-215","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Ichthyosis Follicularis with Alopecia and Photophobia Syndrome with Coexisting Palmoplantar Keratoderma Treated with Acitretin"],"prefix":"10.4103","volume":"14","author":[{"given":"Supriya","family":"Rajesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eswari","family":"Loganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha Gowrappala","family":"Shanmukhappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240903","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1172-6-29","article-title":"Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome","volume":"6","author":"M\u00e9garban\u00e9","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"R2-6-20240903","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ajhg.2009.03.014","article-title":"IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response","volume":"84","author":"Oeffner","year":"2009","journal-title":"Am J Hum Genet"},{"key":"R3-6-20240903","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4103\/idoj.IDOJ_19_19","article-title":"Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome: A case report and review of cases reported from India","volume":"10","author":"Bains","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"R4-6-20240903","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5070\/D37XK9M91H","article-title":"Ichthyosis follicularis with congenital atrichia, nail dystrophy and palmoplantar keratoderma. Variant of IFAP syndrome or a new entity?","volume":"11","author":"Rai","year":"2005","journal-title":"Dermatol Online J"},{"key":"R5-6-20240903","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1067\/mjd.2002.112930","article-title":"Ichthyosis follicularis with atrichia and photophobia (IFAP) syndrome in two unrelated female patients","volume":"46","author":"Cambiaghi","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"R6-6-20240903","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/ijt.ijt_69_16","article-title":"Ichthyosis follicularis, alopecia, and photophobia syndrome","volume":"9","author":"Nagakeerthana","year":"2017","journal-title":"Int J Trichology"},{"key":"R7-6-20240903","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3315\/jdcr.2011.1064","article-title":"Photoletter to the editor: A new variant of ichthyosis follicularis with alopecia and photophobia (IFAP) syndrome with coexisting psoriasiform lesions and palmoplantar keratoderma. IFAP-PPK syndrome?","volume":"5","author":"Alshami","year":"2011","journal-title":"J Dermatol Case Rep"},{"key":"R8-6-20240903","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1468-3083.2005.01318.x","article-title":"Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome treated with acitretin","volume":"19","author":"Khandpur","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_9_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:06:28Z","timestamp":1787760388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_9_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_9_22","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}