{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:43Z","timestamp":1786728643653,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The comparative efficacy of magnetic resonance imaging (MRI)\/ultrasound fusion-guided targeted biopsy (MRI-TBx) versus systematic ultrasound-guided biopsy (TRUS-Bx) for the detection of prostate cancer (PCa) in men with prior negative biopsies remains clinically undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This Preferred Reporting Items for Systematic Reviews and Meta-Analyses-adherent meta-analysis searched Web of Science, PubMed, and EMBASE (through December 2024) for studies comparing MRI-TBx and TRUS-Bx in repeat biopsy cohorts. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Pooled analysis of seven studies (including two randomized trials) involving 459 patients with prior negative biopsies showed that the overall cancer detection rates were comparable: 73% (172\/235) with MRI-TBx versus 77% (181\/235) with TRUS-Bx (RR = 0.97, 95% CI = 0.82\u20131.14,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.232). However, MRI-TBx detected a higher proportion of clinically significant PCa (Gleason score s7) (84.4% vs. 65.1%) and reduced the diagnosis of indolent cancer (Gleason score &lt;7), whereas TRUS-Bx showed superior detection of anterior prostate tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although aggregate detection rates are comparable, MRI-TBx and TRUS-Bx exhibit complementary strengths: MRI-TBx reduces overdiagnosis of indolent cancer, whereas TRUS-Bx ensures sampling of anterior tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/iju.iju_188_25","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:00:09Z","timestamp":1768910409000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic resonance imaging\/ultrasound fusion-guided targeted biopsy and ultrasound-guided systematic biopsy for prior negative prostate biopsy: A meta-analysis"],"prefix":"10.4103","volume":"42","author":[{"given":"Chaoyang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Du","sequence":"additional","affiliation":[{"name":"Nanchang University, Nanchang, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, 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