{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:33:55Z","timestamp":1786739635262,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      White light cystoscopy (WLC) often fails to detect flat or subtle bladder lesions. Enhanced imaging techniques offer improved detection. The Storz Professional Image Enhancement System (SPIES\n                      <jats:sup>TM<\/jats:sup>\n                      ) overcomes these limitations and enables concurrent display of WLC and enhanced images, potentially improving tumor detection. In this study, the SPIES\n                      <jats:sup>TM<\/jats:sup>\n                      system was integrated into the diagnostic cystoscopy protocol to compare Spectra\n                      <jats:sup>TM<\/jats:sup>\n                      modes with conventional WLC in the diagnosis of bladder lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This 1-year prospective observational pilot study included 150 patients with suspected or known bladder tumors. Each patient initially underwent WLC, followed by Spectra B\n                      <jats:sup>TM<\/jats:sup>\n                      and Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      modes. Lesions were mapped according to EAU guidelines; suspicious areas were biopsied or resected for histopathological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      WLC showed a sensitivity of 96% and specificity of 45%, with a false positive rate (FPR) of 54.5%. After WLC, Spectra B did not detect any additional lesions, whereas Spectra A identified three additional lesions, including a T2 recurrence. Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      had 100% sensitivity, but lower specificity (35%) and higher FPR (65%). Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      detected more lesions than WLC, although the difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.131). The increase in FPR of the Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      showed higher sensitivity and identified additional cancerous lesions, including one muscle-invasive tumor missed by WLC. However, it also had a significantly higher FPR. While promising, it has its limitations. Spectra A\n                      <jats:sup>TM<\/jats:sup>\n                      shows potential and warrants further research in larger, multicenter trials.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/iju.iju_221_25","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:00:10Z","timestamp":1770130810000},"page":"128-132","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison between spectra modes of STORZ professional image enhancement systemTM and white light cystoscopy in diagnosis of bladder lesions"],"prefix":"10.4103","volume":"42","author":[{"given":"Kunal","family":"Vinayak","sequence":"first","affiliation":[{"name":"Department of Urology and Kidney Transplant, Artemis Health Institute, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash 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