{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:04Z","timestamp":1786649824396,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sarcopenia, defined as a loss of skeletal muscle mass and strength, has been associated with adverse surgical and oncologic outcomes in various malignancies. This study aimed to evaluate whether the psoas muscle area and psoas muscle index (PMI), derived from the preoperative computed tomography imaging, could predict postoperative complications and long-term oncological outcomes in patients undergoing radical cystectomy (RC) for bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 197 patients who underwent RC between 2014 and 2024. Sarcopenia was defined using sex-specific PMI thresholds based on the lowest quartile for the study population (&lt;7.11 cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      for men and &lt;8.85 cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      for women). Postoperative complications and oncologic outcomes, including overall survival (OS), recurrence-free survival (RFS), and disease-specific mortality (DSM), were assessed using logistic regression and Cox models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sarcopenia was present in 24% of the patients. While the 90-day urinary tract infection and readmissions appeared more frequent in sarcopenic women on the univariate analysis, only the readmission rate remained significant after adjustment. Among the men, although the association between sarcopenia and 30-day complications did not reach statistical significance (odds ratio: 2.10, P = 0.075), the effect size suggested a potential trend toward increased risk. Sarcopenia was not an independent predictor of other 30- or 90-day complications, nor of OS, RFS, or DSM. The median follow-up was 30 months (range: 0\u2013129).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cohort, PMI-based sarcopenia did not independently predict perioperative complications or long-term oncologic outcomes after RC. These findings suggest that PMI alone may not be a robust indicator of surgical risk or oncologic prognosis in bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/iju.iju_385_25","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T15:00:32Z","timestamp":1766934032000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The role of psoas muscle index in predicting outcomes after radical cystectomy"],"prefix":"10.4103","volume":"42","author":[{"given":"Sara L.","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Department of Radiology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Fel\u00edcio","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Silva","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe A.","family":"Gaboleiro","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 J.","family":"Pita","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Carmali","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio M.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 P.","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia A.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Urology, Amadora-Sintra Local Health Unit, Hospital Professor Dr. Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"R1-20251229","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.eururo.2025.02.019","article-title":"European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer:Summary of the 2025 guidelines","volume":"87","author":"van der Heijden","year":"2025","journal-title":"Eur Urol"},{"key":"R2-20251229","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.urolonc.2017.10.002","article-title":"Asystematic review and meta-analysis on the oncological long-term outcomes after trimodality therapy and radical cystectomy with or without neoadjuvant chemotherapy for muscle-invasive bladder cancer","volume":"36","author":"Fahmy","year":"2018","journal-title":"Urol Oncol"},{"key":"R3-20251229","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jcsm.12279","article-title":"Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer","volume":"9","author":"Mayr","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"R4-20251229","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia:Revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"R5-20251229","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2147\/RMHP.S257677","article-title":"Total psoas area index is valuable to assess sarcopenia, sarcopenic overweight\/obesity and predict outcomes in patients undergoing open pancreatoduodenectomy","volume":"13","author":"Xu","year":"2020","journal-title":"Risk Manag Healthc Policy"},{"key":"R6-20251229","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.18632\/oncotarget.27719","article-title":"A low psoas muscle volume is associated with a poor prognosis in penile cancer","volume":"11","author":"Takkamoto","year":"2020","journal-title":"Oncotarget"},{"key":"R7-20251229","doi-asserted-by":"crossref","first-page":"102373","DOI":"10.1016\/j.clgc.2025.102373","article-title":"Impact of muscle depletion on prognosis in patients undergoing radical cystectomy","volume":"23","author":"Pang","year":"2025","journal-title":"Clin Genitourin Cancer"},{"key":"R8-20251229","first-page":"81","article-title":"Sarcopenia is an independent predictor of survival in patients undergoing radical cystectomy for bladder cancer:A single-centre, retrospective study","volume":"76","author":"Erdik","year":"2023","journal-title":"Cent European J Urol"},{"key":"R9-20251229","doi-asserted-by":"crossref","first-page":"901851","DOI":"10.1155\/2015\/901851","article-title":"Total psoas area predicts complications following radical cystectomy","volume":"2015","author":"Lyon","year":"2015","journal-title":"Adv Urol"},{"key":"R10-20251229","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.urology.2021.08.013","article-title":"Psoas muscle mass can predict postsurgical outcomes in patients who undergo radical cystectomy and urinary diversion reconstruction","volume":"158","author":"Stangl-Kremser","year":"2021","journal-title":"Urology"},{"key":"R11-20251229","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11605-013-2148-y","article-title":"Defining postoperative ileus:Results of a systematic review and global survey","volume":"17","author":"Vather","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"R12-20251229","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/000313481708301120","article-title":"The effect of sarcopenia on outcomes in geriatric blunt trauma","volume":"83","author":"Malekpour","year":"2017","journal-title":"Am Surg"},{"key":"R13-20251229","doi-asserted-by":"crossref","first-page":"21514593231195244","DOI":"10.1177\/21514593231195244","article-title":"Psoas muscle morphology as a sarcopenia marker to predict outcomes of geriatric trauma patients:A systematic review and meta-analysis","volume":"14","author":"Wang","year":"2023","journal-title":"Geriatr Orthop Surg Rehabil"}],"container-title":["Indian Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/iju.iju_385_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:51Z","timestamp":1786647531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/iju.iju_385_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,27]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/iju.iju_385_25","relation":{},"ISSN":["0970-1591","1998-3824"],"issn-type":[{"value":"0970-1591","type":"print"},{"value":"1998-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,27]]},"assertion":[{"value":"2025-08-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}