{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:33:58Z","timestamp":1787841238513,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Google Trends (GT) offers the novel approach for real-time monitoring of pregabalin-related online interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We examined whether the online interest in pregabalin captured by GT could approximate temporal trends and correlate with cross-national and state-level patterns of pregabalin consumption globally and in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relative Search Volume (RSV) for \u201cpregabalin\u201d was retrieved from GT for global and Indian data (2008\u20132018). Consumption data were sourced from the IQVIA-MIDAS database and expressed as defined daily doses per 10,000 inhabitants per day (DDD\/TID). For India, in the absence of state-level pregabalin consumption data, prevalence of opioid and sedative use was used as proxy indicators. Temporal trends were analyzed using Locally Weighted Scatterplot Smoothing, changepoint analysis, and cross-correlation function (CCF) with lagged regression. Pearson\u2019s correlation assessed cross-sectional associations between RSV and consumption data across 42 countries (2018) and 32 Indian states (2019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Online interest in pregabalin increased significantly over time globally (F = 202.28,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). CCF analysis showed strongest association at lag 0 (XCF = 0.98,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001), indicating that online search interest and actual consumption occurred concurrently in the same year. RSV and pregabalin consumption were modestly correlated across countries (r = 0.44,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003). In India, state-level RSV moderately correlated with opioid (r = 0.44,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) and sedative (r = 0.37,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GT has a potential role in monitoring online interest related to pregabalin, which may serve as an indirect indicator of public engagement or awareness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/indianjpsychiatry_401_25","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T13:08:33Z","timestamp":1758028113000},"page":"885-893","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring pregabalin use through online interest: A trend analysis using google search and consumption data"],"prefix":"10.4103","volume":"67","author":[{"given":"Abhishek","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Drug Deaddiction and Treatment Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simranjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Thapar Institute of Engineering and Technology (Deemed to be University), Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjini","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"R1-20250916","doi-asserted-by":"crossref","first-page":"709","DOI":"10.5414\/CP202118","article-title":"Pregabalin\u2019s abuse potential: A mini review focusing on the pharmacological profile","volume":"52","author":"Papazisis","year":"2014","journal-title":"Int J Clin Pharmacol Ther"},{"key":"R2-20250916","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00228-010-0853-y","article-title":"A signal for an abuse liability for pregabalin\u2014Results from the Swedish spontaneous adverse drug reaction reporting system","volume":"66","author":"Schwan","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"R3-20250916","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1038\/s41598-019-51556-4","article-title":"Pregabalin: Potential for addiction and a possible glutamatergic 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