{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:32Z","timestamp":1787169512699,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Obsessive\u2013compulsive disorder (OCD) is associated with poor quality of life (QoL) and functionality. Treatment leads to improvement in QoL and better functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the effect of treatment with SSRIs on QoL and disability in first-episode, drug-na\u00efve patients with OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Fifty first-episode, drug-na\u00efve patients with a diagnosis of OCD according to the Diagnostic and Statistical Manual 5 were assessed for severity of illness (Y-BOCS), World Health Organization QoL (WHO-QoL Bref), and disability (WHODAS 2.0) at baseline and at 12 weeks after receiving treatment with either sertraline or fluvoxamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The scores for QoL were low and for disability were high at baseline, and the scores for WHO-QoL-Bref and WHODAS 2.0 improved significantly after 12 weeks of treatment compared to baseline. This improvement correlated with reduction in the illness severity scores on Yale-Brown Obsessive\u2013Compulsive Scale. The responders to treatment had better QoL and lower disability compared to nonresponders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is an impairment in QoL and disability in first-episode, drug-na\u00efve patients with OCD, and QoL improves and disability decreases with adequate treatment with SSRIs, and this improvement correlates with improvement in the illness severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ipj.ipj_133_21","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T07:07:26Z","timestamp":1646291246000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effect of sertraline and fluvoxamine on quality of life in patients with obsessive\u2013compulsive disorder"],"prefix":"10.4103","volume":"31","author":[{"given":"Jasmine","family":"Brar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet","family":"Sidana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240829","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: Beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"R2-4-20240829","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0022-3859.40773","article-title":"Family burden, quality of life and disability in obsessive compulsive disorder: An Indian perspective","volume":"54","author":"Gururaj","year":"2008","journal-title":"J Postgrad Med"},{"key":"R3-4-20240829","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1607-551X(10)70065-6","article-title":"Quality of life and its correlates in patients with obsessive-compulsive disorder","volume":"26","author":"Hou","year":"2010","journal-title":"Kaohsiung J Med Sci"},{"key":"R4-4-20240829","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1176\/ps.50.3.412","article-title":"Quality-of-life changes among patients with obsessive-compulsive disorder in a partial hospitalization program","volume":"50","author":"Bystritsky","year":"1999","journal-title":"Psychiatr Serv"},{"key":"R5-4-20240829","first-page":"C04","article-title":"Assessment of quality of life (QOL) in obsessive compulsive disorder (OCD) and dysthymic disorder (DD): A comparative study","volume":"9","author":"Vasudev","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"R6-4-20240829","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1017\/S1092852912000697","article-title":"Quality of life in obsessive compulsive disorder","volume":"18","author":"Macy","year":"2013","journal-title":"CNS Spectr"},{"key":"R7-4-20240829","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ajp.2011.05.008","article-title":"Quality of life in patients with obsessive compulsive disorder: A longitudinal study from India","volume":"4","author":"Srivastava","year":"2011","journal-title":"Asian J Psychiatr"},{"key":"R9-4-20240829","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. 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