{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:26:45Z","timestamp":1786728405366,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    Prostate cancer is a common oncological disease of old age with the highest rates of incidence among males older than 65 years old. Diagnosis and treatment may be associated with the onset of adjustment, depressive, and anxiety disorders. The comorbidity with depression and anxiety may lead to a higher risk of suicide, and mortality as well as lower adherence to medical treatments and adverse functional outcomes in patients affected by urologic cancers. The role of genetic vulnerability and pre-morbid personality in predicting the development of mental disorders during cancer disease is debated. For instance, some genetic polymorphisms of the serotonin transporter-related promoter region (5-HTTLPR polymorphism) are associated with higher vulnerability for mental disorders as well as personality traits of neuroticism; both factors are potentially useful for identifying risk of depressive and anxious symptoms among cancer patients. This communication proposes the development of individualized psychobiological approaches to identify possible\n                    <jats:italic toggle=\"yes\">\u2018psychobiological\u2019<\/jats:italic>\n                    markers associated with the risk of mental disorders in prostate cancer patients.\n                  <\/jats:p>","DOI":"10.4103\/ipj.ipj_212_23","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T13:05:32Z","timestamp":1701263132000},"page":"S273-S276","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Psychobiological screening among patients affected by prostate cancer: Identification of potential psychobiological markers"],"prefix":"10.4103","volume":"32","author":[{"given":"Melania","family":"Severo","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"},{"name":"Department of Humanistic Studies, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ventriglio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Bhugra","sequence":"additional","affiliation":[{"name":"Emeritus Professor of Mental Health and Cultural Diversity, King's College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Petito","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"R1-20260512","article-title":"Key Statistics for Prostate Cancer","year":"2023"},{"key":"R2-20260512","doi-asserted-by":"crossref","first-page":"c4543","DOI":"10.1136\/bmj.c4543","article-title":"Screening for prostate cancer: Systematic review and meta-analysis of randomised controlled trials","volume":"341","author":"Djulbegovic","year":"2010","journal-title":"BMJ"},{"key":"R4-20260512","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1475-2891-9-50","article-title":"A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer","volume":"9","author":"Alexander","year":"2010","journal-title":"Nutr J"},{"key":"R5-20260512","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/pros.21235","article-title":"Meta-analysis of genome-wide and replication association studies on prostate cancer","volume":"71","author":"Liu","year":"2011","journal-title":"Prostate"},{"key":"R6-20260512","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/07347332.2016.1225145","article-title":"Personality and psychological distress among older adult, long-term cancer survivors","volume":"35","author":"Deimling","year":"2017","journal-title":"J Psychosoc Oncol"},{"key":"R7-20260512","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1037\/0278-6133.24.5.508","article-title":"Optimistic personality and psychosocial well-being during treatment predict psychosocial well-being among long-term survivors of breast cancer","volume":"24","author":"Carver","year":"2005","journal-title":"Health Psychol"},{"key":"R8-20260512","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/02841860701798858","article-title":"Personality and choice of coping predict quality of life in head and neck cancer patients during follow-up","volume":"47","author":"Aarstad","year":"2008","journal-title":"Acta Oncol"},{"key":"R9-20260512","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/pon.1536","article-title":"Personality traits and psychosocial stress: Quality of life over 2 years following breast cancer diagnosis and psychological impact factors","volume":"19","author":"Ha\u0308rtl","year":"2010","journal-title":"Psychooncol"},{"key":"R10-20260512","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s001270200014","article-title":"Association between physical illness and suicide among the elderly","volume":"37","author":"Quan","year":"2002","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"R11-20260512","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41391-020-00286-0","article-title":"Depression, anxiety, and suicidality in patients with prostate cancer: A systematic review and meta-analysis of observational studies","volume":"24","author":"Brunckhorst","year":"2021","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"R12-20260512","doi-asserted-by":"crossref","first-page":"e2140803","DOI":"10.1001\/jamanetworkopen.2021.40803","article-title":"Association of second- generation antiandrogens with depression among patients with prostate cancer","volume":"4","author":"Nowakowska","year":"2021","journal-title":"JAMA Netw open"},{"key":"R13-20260512","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/oncolo\/oyab033","article-title":"Depression, anxiety, and patterns of mental health care among men with prostate cancer receiving androgen deprivation therapy","volume":"27","author":"Tsao","year":"2022","journal-title":"Oncologist"},{"key":"R14-20260512","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/13685538.2022.2053954","article-title":"Androgen deprivation therapy and depression in the prostate cancer patients: Review of risk and pharmacological management","volume":"25","author":"Alwhaibi","year":"2022","journal-title":"The Aging Male"},{"key":"R15-20260512","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/cncr.33397","article-title":"Systemic inflammation and symptomatology in patients with prostate cancer treated with androgen deprivation therapy: Preliminary findings","volume":"127","author":"Hoogland","year":"2021","journal-title":"Cancer"},{"key":"R16-20260512","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1002\/cncr.22294","article-title":"Biomarkers of depression in cancer patients","volume":"107","author":"Jehn","year":"2006","journal-title":"Cancer"},{"key":"R17-20260512","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2006.11.004","article-title":"The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review","volume":"21","author":"Schubert","year":"2007","journal-title":"Brain Behav Immun"},{"key":"R18-20260512","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1158\/1078-0432.CCR-08-2584","article-title":"Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer","volume":"15","author":"Bower","year":"2009","journal-title":"Clin Cancer Res"},{"key":"R19-20260512","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1017\/S0033291717000150","article-title":"Depressive symptoms and inflammation are independent risk factors of fatigue in breast cancer survivors","volume":"47","author":"Xiao","year":"2017","journal-title":"Psychol Med"},{"key":"R20-20260512","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/1097-0142(20010915)92:6+<1664::AID-CNCR1494>3.0.CO;2-9","article-title":"Interferon-mediated fatigue","volume":"92","author":"Malik","year":"2001","journal-title":"Cancer"},{"key":"R21-20260512","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.urolonc.2021.08.003","article-title":"Anxiety, depression and urological cancer outcomes: A systematic review","volume":"39","author":"Dinesh","year":"2021","journal-title":"Urol Oncol"},{"key":"R22-20260512","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s11845-020-02417-x","article-title":"Post-surgery anxiety and depression in prostate cancer patients: Prevalence, longitudinal progression, and their correlations with survival profiles during a 3-year follow-up","volume":"190","author":"Hu","year":"2021","journal-title":"Ir J Med Sci"},{"key":"R23-20260512","doi-asserted-by":"crossref","first-page":"e003901","DOI":"10.1136\/bmjopen-2013-003901","article-title":"Depression and anxiety in prostate cancer: A systematic review and meta\u2010analysis of prevalence rates","volume":"4","author":"Watts","year":"2014","journal-title":"BMJ Open"},{"key":"R24-20260512","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/pon.5377","article-title":"Association of persona- lity profiles with coping and adjustment to cancer among patients undergoing chemotherapy","volume":"29","author":"Langford","year":"2020","journal-title":"Psychooncol"},{"key":"R25-20260512","first-page":"156","article-title":"Associations between personality traits, perceived stress and depressive symptoms in gynecological cancer patients characterized by the short and long allele variant of the 5-HTTLPR genotype: Preliminary results","volume":"19","author":"Iuso","year":"2022","journal-title":"Clin Neuropsychiatry"},{"key":"R26-20260512","doi-asserted-by":"crossref","first-page":"962948","DOI":"10.3389\/fpsyt.2022.962948","article-title":"Perinatal depression screening and prevention: Descriptive findings from a multicentric program in the South of Italy","volume":"13","author":"Bellomo","year":"2022","journal-title":"Front Psychiatry"},{"key":"R27-20260512","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1601-183X.2011.00690.x","article-title":"Serotonin transporter gene variants and prediction of stress-induced risk for psychological distress","volume":"10","author":"Stefanis","year":"2011","journal-title":"Genes Brain Behav"},{"key":"R28-20260512","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2174\/1381612821666150105121244","article-title":"Early-life stress and psychiatric disorders: Epidemiology, neurobiology and innovative pharmacological targets","volume":"21","author":"Ventriglio","year":"2015","journal-title":"Curr Pharm Des"},{"key":"R29-20260512","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.biopsych.2005.04.050","article-title":"The serotonin transporter length polymorphism, neuroticism, and depression: A comprehensive assessment of association","volume":"58","author":"Willis-Owen","year":"2005","journal-title":"Biol Psychiatry"},{"key":"R30-20260512","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2174\/138945006779025419","article-title":"Serotonin transporter gene variants and behavior: A comprehensive review","volume":"7","author":"Serretti","year":"2006","journal-title":"Curr Drug Targets"},{"key":"R31-20260512","doi-asserted-by":"crossref","first-page":"e0156601","DOI":"10.1371\/journal.pone.0156601","article-title":"The relationship between personality traits, the 5HTT polymorphisms, and the occurrence of anxiety and depressive symptoms in elite athletes","volume":"11","author":"Petito","year":"2016","journal-title":"PLoS One"},{"key":"R32-20260512","first-page":"259","article-title":"Examination of associations between personality traits, and polymorphisms of MAO-A and 5-HTT with the severity of menopausal symptoms and depression levels","volume":"12","author":"Esmaeilzadeh","year":"2020","journal-title":"Biomed Rep"},{"key":"R33-20260512","first-page":"1181","article-title":"Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients","volume":"26","author":"Kim","year":"2018","journal-title":"Support Care Cancer"},{"key":"R34-20260512","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1017\/S2045796015000608","article-title":"Descartes' dogma and damage to Western psychiatry","volume":"24","author":"Ventriglio","year":"2015","journal-title":"Epidemiol Psychiatr Sci"},{"key":"R35-20260512","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/wps.20381","article-title":"Mind and body: Physical health needs of individuals with mental illness in the 21st century","volume":"16","author":"Bhugra","year":"2017","journal-title":"World Psychiatry"}],"container-title":["Industrial Psychiatry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ipj.ipj_212_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:38Z","timestamp":1786724798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ipj.ipj_212_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":34,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ipj.ipj_212_23","relation":{},"ISSN":["0972-6748","0976-2795"],"issn-type":[{"value":"0972-6748","type":"print"},{"value":"0976-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-08-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}