{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:08Z","timestamp":1788675428609,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Pregabalin, a gamma-aminobutyric acid (GABA) analog, is a new-generation antiepileptic that is approved for the treatment of neuropathic pain, fibromyalgia, partial seizures, and generalized anxiety disorder. There is a rising concern regarding its abuse potential, and a handful of case reports have highlighted the same. We present a case series on pregabalin dependence. In contrast to previous case reports, which focused on patients with a history of illicit drug abuse, we present cases of drug-na\u00efve individuals for whom pregabalin was the first substance of abuse. The highlight of the study is that we describe cases of pregabalin intoxication and a rare case of pregabalin withdrawal, which presented as a lethal suicidal attempt to liaison psychiatric settings.<\/jats:p>","DOI":"10.4103\/ipj.ipj_474_24","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T07:00:18Z","timestamp":1744959618000},"page":"114-116","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Pregabalin dependence: Experiences from liaison psychiatric settings in Kashmir, North India: A case series"],"prefix":"10.4103","volume":"34","author":[{"given":"Aaliya","family":"Khanam","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid A.","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir H.","family":"Rather","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"R1-20260423","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s40263-014-0164-4","article-title":"Misuse and abuse of pregabalin and gabapentin: Cause for concern?","volume":"28","author":"Schifano","year":"2014","journal-title":"CNS Drugs"},{"issue":"Suppl 1","key":"R2-20260423","doi-asserted-by":"crossref","first-page":"S352","DOI":"10.4103\/0972-6748.328855","article-title":"A case of pregabalin addiction","volume":"30","author":"Sahu","year":"2021","journal-title":"Ind Psychiatry J"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40265-020-01432-7","article-title":"Abuse and misuse of pregabalin and gabapentin: A systematic review update","volume":"81","author":"Evoy","year":"2021","journal-title":"Drugs"},{"key":"R4-20260423","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s40264-020-00985-6","article-title":"Current evidence on abuse and misuse of gabapentinoids","volume":"43","author":"H\u00e4gg","year":"2020","journal-title":"Drug Saf"},{"key":"R5-20260423","first-page":"218","article-title":"Depressive disorder following withdrawal pregabalin: A case report","volume":"47","author":"G\u00fcndo\u011fmu\u015f","year":"2021","journal-title":"Arch Clin Psychiatry S\u00e3o Paulo"},{"key":"R6-20260423","doi-asserted-by":"crossref","first-page":"37.","DOI":"10.1186\/s12991-014-0037-8","article-title":"Depression and attempted suicide under pregabalin therapy","volume":"13","author":"Kustermann","year":"2014","journal-title":"Ann Gen Psychiatry"},{"key":"R7-20260423","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/npr2.12195","article-title":"Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review","volume":"41","author":"Ishikawa","year":"2021","journal-title":"Neuropsychopharmacol Rep"},{"key":"R8-20260423","doi-asserted-by":"crossref","first-page":"979.","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_283_23","article-title":"Very high dose of pregabalin abuse: A case report","volume":"65","author":"Gupta","year":"2023","journal-title":"Indian J Psychiatry"}],"container-title":["Industrial Psychiatry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ipj.ipj_474_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:53Z","timestamp":1786647473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ipj.ipj_474_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ipj.ipj_474_24","relation":{},"ISSN":["0972-6748","0976-2795"],"issn-type":[{"value":"0972-6748","type":"print"},{"value":"0976-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}