{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:44Z","timestamp":1787761964121,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Studies have hypothesized the role of the immune\u2013inflammatory process behind the pathophysiology of psychiatric disorders like schizophrenia. Antipsychotic medication has been shown to suppress inflammatory response via complex mechanisms alleviating psychiatric symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the relation of neutrophil-to-lymphocyte ratio (NLR) with antipsychotic administration and clinical symptomatology severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A longitudinal study was performed among 34 inpatients who fulfilled inclusion and exclusion criteria. Sociodemographic details were collected, and the brief psychiatric rating scale (BPRS) was applied during admission. Blood sampling was performed during baseline and at discharge for the NLR ratio (neutrophil count\/lymphocyte count) with the application of BPRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean \u00b1 SD age of the population was 38.91 \u00b1 11.44 years, with male gender predominance (N = 25, 73.5%). The median duration of illness and duration of treatment were 10 months and 40 days, respectively. Twelve (35.3%) subjects were antipsychotic na\u00efve. The mean \u00b1 SD of BPRS and NLR during admission was 49.94 \u00b1 5.33 and 2.49 \u00b1 0.92 and during discharge was 26.76 \u00b1 6.04 and 2.08 \u00b1 0.72, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results confirmed the NLR-lowering effect of antipsychotics alongside lowering of clinical symptomatology. NLR has the potential to be a biomarker indicating antipsychotic treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ipj.ipj_6_25","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T07:00:08Z","timestamp":1744959608000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Association of neutrophil-to-lymphocyte ratio with antipsychotic administration in schizophrenia: A longitudinal study"],"prefix":"10.4103","volume":"34","author":[{"given":"Rajnish","family":"Raj","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabir Ahmad","family":"Dar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav Kumar","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Mental Health and Neurosciences Kashmir, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inaamul","family":"Haq","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"R2-20260423","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00213-015-3975-1","article-title":"Is there a role for immune-to-brain communication in schizophrenia?","volume":"233","author":"Khandaker","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fpsyt.2019.00892","article-title":"Cytokine alterations in schizophrenia: An updated review","volume":"10","author":"Momtazmanesh","year":"2019","journal-title":"Front Psychiatry"},{"key":"R4-20260423","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41380-018-0220-4","article-title":"Cerebrospinal fluid markers of inflammation and infections in schizophrenia and affective disorders: A systematic review and meta-analysis","volume":"24","author":"Orlovska-Waast","year":"2019","journal-title":"Mol Psychiatry"},{"key":"R5-20260423","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41380-018-0058-9","article-title":"Is psychosis a multisystem disorder? 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