{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:30:25Z","timestamp":1789122625131,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Preeclampsia (PE) is a gestational-related disease presented with hypertension, peripheral edema, and proteinuria after 20 weeks of gestation. In PE, there are various metabolic changes like dyslipidemia. In addition, both PE and dyslipidemia are associated with changes of platelet indices. Thus, objective of the current study was to illustrate the potential role of dyslipidemia and platelet changes in pregnant women with PE. This case\u2013control study involved 37 preeclamptic pregnant women as compared to 24 healthy pregnant women as controls. Blood pressure profile, lipid profile, proteinuria, and platelet indices were measured. Blood pressure profile was higher in preeclamptic pregnant women as compared to the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). There was a significant dyslipidemic status in preeclamptic pregnant women compared with the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Platetetcrit (PCT) and platelet count (PC) were lower in preeclamptic pregnant women compared with the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). On the other hand, platelet distribution width (PDW), mean platelet volume (MPV), and platelet-large cell ratio (P-LCR) were higher in the pregnant women with PE as compared with the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). PCT and PC were insignificantly linked, while P-LCR, MPV and PDW were significantly correlated with total cholesterol, triglyceride, low-density lipoprotein (LDL)\/high-density lipoprotein (HDL) ratio, systolic blood pressure, DBP, and MAP in preeclamptic patients compared with women of normal pregnancy. Both dyslipidemia and alterations in the platelet indices are correlated with blood pressure profile in PE. High MPV and PDW in association with high LDL\/HDL ratio in pregnant women herald risk of PE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/japtr.japtr_104_20","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T07:28:33Z","timestamp":1610177313000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Role of dyslipidemia in the development of early-onset preeclampsia"],"prefix":"10.4103","volume":"12","author":[{"given":"Thabat J.","family":"Al-Maiahy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali I.","family":"Al-Gareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al-Kuraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20240903","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4103\/JLP.JLP_26_18","article-title":"Concept and connotation of oxidative stress in preeclampsia","volume":"10","author":"Al-Kuraishy","year":"2018","journal-title":"J Lab Physicians"},{"key":"R2-13-20240903","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/japtr.JAPTR_297_18","article-title":"A comparative study on infusion of usual dose of oxytocin and 80 units dose of oxytocin in the prevention of postpartum hemorrhage in cesarean section","volume":"9","author":"Ahmadi","year":"2018","journal-title":"J Adv Pharm Technol Res"},{"key":"R3-13-20240903","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/2305-0500.259168","article-title":"Prolactin and risk of preeclampsia: A single institution, cross-sectional study","volume":"8","author":"Al-Maiahy","year":"2019","journal-title":"Asian Pac J Reprod"},{"key":"R4-13-20240903","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/japtr.JAPTR_371_18","article-title":"Effect of cell-free fetal DNA on spontaneous preterm labor","volume":"10","author":"Darghahi","year":"2019","journal-title":"J Adv Pharm Technol Res"},{"key":"R5-13-20240903","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5114\/aoms.2018.81035","article-title":"Increased platelet reactivity in dyslipidemic patients with coronary artery disease on dual anti-platelet therapy","volume":"15","author":"J\u00e4ger","year":"2019","journal-title":"Arch Med Sci"},{"key":"R6-13-20240903","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.htct.2018.08.008","article-title":"A correlation between platelet indices and preeclampsia","volume":"41","author":"Thalor","year":"2019","journal-title":"Hematol Transfus Cell Ther"},{"key":"R7-13-20240903","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.preghy.2019.08.003","article-title":"Platelet count and mean platelet volume predict atypical pre-eclampsia","volume":"18","author":"Zhang","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"R8-13-20240903","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/AOG.0000000000002564","article-title":"A comparison of methods for the diagnosis of fetal growth restriction between the royal college of obstetricians and gynaecologists and the American College of Obstetricians and Gynecologists","volume":"131","author":"Blue","year":"2018","journal-title":"Obstet Gynecol"},{"key":"R9-13-20240903","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/0976-0105.195080","article-title":"Effects of Rosuvastatin Alone or in Combination with Omega-3 Fatty Acid on Adiponectin Levels and Cardiometabolic Profile","volume":"8","author":"Al-Kuraishy","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"R10-13-20240903","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4103\/JLP.JLP_123_19","article-title":"Endothelial dysfunction and inflammatory biomarkers as a response factor of concurrent coenzyme Q10 add-on metformin in patients with type 2 diabetes mellitus","volume":"11","author":"Al-Kuraishy","year":"2019","journal-title":"J Lab Physicians"},{"key":"R11-13-20240903","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.preghy.2017.01.005","article-title":"Visual or automated dipstick testing for proteinuria in pregnancy.?","volume":"7","author":"Correa","year":"2017","journal-title":"Pregnancy Hypertension"},{"key":"R12-13-20240903","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2305-0500.275522","article-title":"Testosterone is a surrogate and proxy biomarker for severity of late-onset preeclampsia: A cross-sectional study","volume":"9","author":"Al-Maiahy","year":"2020","journal-title":"Asian Pac J Reprod"},{"key":"R13-13-20240903","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/japtr.JAPTR_65_19","article-title":"Effects of diabetic pharmacotherapy on prolactin hormone in patients with type 2 diabetes mellitus: Bane or boon","volume":"10","author":"Rasheed","year":"2019","journal-title":"J Adv Pharm Technol Res"},{"key":"R14-13-20240903","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12916-019-1472-9","article-title":"Use of smoking cessation pharmacotherapies during pregnancy is not associated with increased risk of adverse pregnancy outcomes: A population-based cohort study","volume":"18","author":"Tran","year":"2020","journal-title":"BMC Med"},{"key":"R15-13-20240903","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R16-13-20240903","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.prostaglandins.2018.09.006","article-title":"Role of dyslipidemia in preeclampsia-A review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with preeclampsia","volume":"139","author":"Wojcik-Baszko","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"R17-13-20240903","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/13543784.2018.1465927","article-title":"The potential role of statins in preeclampsia and dyslipidemia during gestation: A narrative review","volume":"27","author":"Maierean","year":"2018","journal-title":"Expert Opin Investig Drugs"},{"key":"R18-13-20240903","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/japtr.JAPTR_98_19","article-title":"Antidiabetic effect of Drymaria cordata leaf against streptozotocin-nicotinamide-induced diabetic albino rats","volume":"11","author":"Patra","year":"2020","journal-title":"J Adv Pharm Technol Res"},{"key":"R19-13-20240903","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.medcli.2013.05.037","article-title":"Atherogenic index of plasma in patients with preeclampsia and in healthy pregnant women","volume":"143","author":"Aragon-Charris","year":"2014","journal-title":"Med Clin (Barc"},{"key":"R20-13-20240903","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/japtr.JAPTR_298_18","article-title":"Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study","volume":"9","author":"Al-Naimi","year":"2018","journal-title":"J Adv Pharm Technol Res"},{"key":"R21-13-20240903","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/JLP.JLP_161_18","article-title":"Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases","volume":"11","author":"Reddy","year":"2019","journal-title":"J Lab Physicians"},{"key":"R22-13-20240903","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/CS20191155","article-title":"Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats","volume":"134","author":"Dutta","year":"2020","journal-title":"Clin Sci (Lond"},{"key":"R23-13-20240903","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/j.preghy.2018.08.372","article-title":"Peculiarities of placental expression of erythropoietin in preeclampsia","volume":"13","author":"Chulkov","year":"2018","journal-title":"Pregnancy Hypertension"},{"key":"R24-13-20240903","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4103\/japtr.JAPTR_28_20","article-title":"Antihyperlipidemic effects of apple peel extract in high-fat diet-induced hyperlipidemic rats","volume":"11","author":"Susilowati","year":"2020","journal-title":"J Adv Pharm Technol Res"},{"key":"R25-13-20240903","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/japtr.JAPTR_280_17","article-title":"The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research","volume":"9","author":"Urakov","year":"2018","journal-title":"J Adv Pharm Technol Res"},{"key":"R26-13-20240903","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.trsl.2018.09.005","article-title":"Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: A novel index for the prediction of HDL functionality","volume":"205","author":"Shih","year":"2019","journal-title":"Transl Res"}],"container-title":["Journal of Advanced Pharmaceutical Technology &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/japtr.JAPTR_104_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:35:57Z","timestamp":1787844957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/japtr.JAPTR_104_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/japtr.japtr_104_20","relation":{},"ISSN":["2231-4040"],"issn-type":[{"value":"2231-4040","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}