{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:46Z","timestamp":1786649806344,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    The health and beauty sectors are significant drivers for the continuous growth of related product markets.\n                    <jats:italic toggle=\"yes\">Solanum trilobatum<\/jats:italic>\n                    L. (\n                    <jats:italic toggle=\"yes\">S. trilobatum<\/jats:italic>\n                    ), locally known as Ma Waeng Krue, is a popular medicinal plant utilized in primary health care in Thailand. Renowned for their remarkable antimicrobial, antioxidant, antibacterial, and antifungal characteristics, the leaves and fruits of this plant yield abundant quantities of saponins, anthraquinones, terpenoids, and tannins. This study investigated the antioxidant activity, total phenolic content (TPC), and inhibitory effects of unripe and ripe\n                    <jats:italic toggle=\"yes\">S. trilobatum<\/jats:italic>\n                    fruit extracts against collagenase, elastase, and hyaluronidase, specifically methanol and ethyl acetate extracts. The ethyl acetate extracts from unripe fruits contained the highest TPC and showed the greatest antioxidant activity as demonstrated by the 2,2\u2019-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and ferric reducing antioxidant power methods. In contrast, methanol extracts from ripe fruits had the highest yield and demonstrated the greatest antioxidant activity according to the 2,2-diphenyl-1-picrylhydrazyl assay. Notably, methanol extracts from unripe fruits exhibited the most potent inhibition of collagenase, elastase, and hyaluronidase compared with ethyl acetate extracts.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_148_25","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:01:46Z","timestamp":1760936506000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of antioxidant, anti collagenase, anti-elastase, and anti-hyaluronidase activities of Solanum trilobatum L. for pharmaceutical development"],"prefix":"10.4103","volume":"16","author":[{"given":"Chanai","family":"Noysang","sequence":"first","affiliation":[{"name":"Department of Innovation of Health Products, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monsicha","family":"Khuanekkaphan","sequence":"additional","affiliation":[{"name":"Department of Health and Aesthetics, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerarat","family":"Pummarin","sequence":"additional","affiliation":[{"name":"Department of Innovation of Health Products, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiphupat","family":"Buranasukhon","sequence":"additional","affiliation":[{"name":"Department of Innovation of Health Products, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em-on","family":"Chaiprateep","sequence":"additional","affiliation":[{"name":"Department of Health and Aesthetics, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"1195272","DOI":"10.3389\/fphys.2023.1195272","article-title":"Skin aging from mechanisms to interventions: Focusing on dermal aging","volume":"14","author":"Shin","year":"2023","journal-title":"Front Physiol"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s41240-020-00149-8","article-title":"In vitro screening of elastase, collagenase, hyaluronidase, and tyrosinase inhibitory and antioxidant activities of 22 halophyte plant extracts for novel 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