{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:23:12Z","timestamp":1787746992853,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Traditionally used to treat inflammatory diseases,\n Kaempferia galanga<\/jats:italic>\n L. includes bioactive substances with anti-inflammatory properties, such as eugenol and ethyl p-methoxycinnamate. Its potential as a topical treatment for wound healing is yet unclear, though. This study aims to assess the ability of\n K<\/jats:italic>\n .\n galanga<\/jats:italic>\n cream (KGC) in accelerating wound healing and to observe its effects on excisional wound models based on plasma levels of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-\u03b1). Six groups (\n n<\/jats:italic>\n = 5) were created from thirty male Wistar rats. After creating a 1.5-cm full-thickness wound on the dorsal side, without treatment as a control, a base cream as a negative control, 10% povidone\u2013iodine cream as a positive control, or KGC (5%, 10%, or 15%) was applied topically every day for 14 days. On days 7 and 14, the ImageJ software was used to quantify the wound area. Plasma TNF-\u03b1 and IL-10 levels were measured on day 15 using enzyme-linked immunosorbent assay, and statistical evaluation was conducted via one-way analysis of variance with Tukey\u2019s\n post hoc<\/jats:italic>\n test. KGC markedly improved wound healing versus the negative control. The 10% formulation produced the greatest effect, reducing wound area by 65.3% on day 14 (\n P<\/jats:italic>\n < 0.001). It also markedly decreased TNF-\u03b1 levels by 38.7% (\n P<\/jats:italic>\n < 0.001) and increased IL-10 levels by 42.5% (\n P<\/jats:italic>\n < 0.001) compared with the negative control. The 10% KGC demonstrated the most effective wound healing activity, likely through modulation of pro- and anti-inflammatory cytokines. These findings support its potential as a topical herbal formulation for wound management.\n <\/jats:p>","DOI":"10.4103\/japtr.japtr_18_26","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:00:16Z","timestamp":1786546816000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferia galanga cream accelerates wound healing through modulation of tumor necrosis factor-alpha and interleukin-10 in an excision wound model"],"prefix":"10.4103","volume":"17","author":[{"given":"Siska","family":"Siska","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujianti","family":"Fujianti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahyatul","family":"Bariroh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supandi","family":"Supandi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islamudin","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"R1-20260826","doi-asserted-by":"crossref","first-page":"012057","DOI":"10.1088\/1755-1315\/819\/1\/012057","article-title":"Chemical component of kencur (Kaemferia galanga L.) Ethanolic extract using gas chromatography-mass spectrometry","volume":"819","author":"Hikmawati","year":"2021","journal-title":"IOP Conf Ser Earth Environ Sci"},{"key":"R2-20260826","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s43094-021-00394-1","article-title":"Phytochemical characterization of the ethanolic extract of Kaempferia galanga rhizome for anti-oxidant activities by HPTLC and GCMS","volume":"8","author":"Nonglang","year":"2022","journal-title":"Futur J Pharm Sci"},{"key":"R3-20260826","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.3390\/molecules17078720","article-title":"Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts","volume":"17","author":"Umar","year":"2012","journal-title":"Molecules"},{"key":"R4-20260826","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jtcme.2021.06.004","article-title":"Extract, fractions, and ethyl-p-methoxycinnamate isolate from Kaempferia galanga Elicit anti-inflammatory activity by limiting leukotriene B4 (LTB4) production","volume":"11","author":"Dwita","year":"2021","journal-title":"J Tradit Complement Med"},{"key":"R5-20260826","doi-asserted-by":"crossref","first-page":"134","DOI":"10.6061\/clinics\/2014(02)10","article-title":"Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-a, and angiogenesis by blocking endothelial functions","volume":"69","author":"Umar","year":"2014","journal-title":"Clinics (Sao Paulo)"},{"key":"R6-20260826","first-page":"384","article-title":"Wound healing activity of alcoholic extract of Kaempferia galanga in Wistar rats","volume":"50","author":"Tara","year":"2006","journal-title":"Indian J Physiol Pharmacol"},{"key":"R7-20260826","doi-asserted-by":"crossref","first-page":"115052","DOI":"10.1016\/j.jep.2022.115052","article-title":"Wound healing properties of pharmaceutical gel containing isopimarane diterpene isolated from Kaempferia galanga L","volume":"289","author":"Sudsai","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"R8-20260826","doi-asserted-by":"crossref","first-page":"e18716","DOI":"10.7717\/peerj.18716","article-title":"Wound healing potential of mouth gel containing isopimarane diterpene from Kaempferia galanga rhizomes for treatment of oral stomatitis","volume":"12","author":"Iadnut","year":"2024","journal-title":"PeerJ"},{"key":"R9-20260826","doi-asserted-by":"crossref","first-page":"117762","DOI":"10.1016\/j.jep.2024.117762","article-title":"Anti-inflammatory and wound healing effects of mouth gel containing kaempulchraol K from Kaempferia galanga rhizomes","volume":"324","author":"Pathan","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"R10-20260826","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2147\/JIR.S359042","article-title":"Anti-inflammatory activity and wound healing effect of Kaempferia galanga L. Rhizome on the chemical-induced oral mucosal ulcer in Wistar rats","volume":"15","author":"Wahyuni","year":"2022","journal-title":"J Inflamm Res"},{"key":"R11-20260826","first-page":"337","article-title":"Ethyl P-methoxycinnamate: An active anti-metastasis agent and chemosensitizer targeting NFkB from Kaempferia galanga for melanoma cells","volume":"12","author":"Lallo","year":"2022","journal-title":"Life (Basel)"},{"key":"R12-20260826","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1134\/S0026893319050121","article-title":"Proinflammatory cytokines and skin wound healing in mice","volume":"53","author":"Nosenko","year":"2019","journal-title":"Mol Biol (Mosk)"},{"key":"R13-20260826","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/antiox13070823","article-title":"OxInflammatory responses in the wound healing process: A systematic review","volume":"13","author":"Lopes","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"R14-20260826","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1111\/iwj.14119","article-title":"Role of macrophage polarisation in skin wound healing","volume":"20","author":"Gao","year":"2023","journal-title":"Int Wound J"},{"key":"R15-20260826","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/wound.2013.0461","article-title":"Regenerative wound healing: The role of interleukin-10","volume":"3","author":"King","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"R16-20260826","doi-asserted-by":"crossref","first-page":"675350","DOI":"10.3389\/fphar.2021.675350","article-title":"Kaempferia galanga L.: Progresses in phytochemistry, pharmacology, toxicology and ethnomedicinal uses","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"}],"container-title":["Journal of Advanced Pharmaceutical Technology & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JAPTR.JAPTR_18_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:00:58Z","timestamp":1787745658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JAPTR.JAPTR_18_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/japtr.japtr_18_26","relation":{},"ISSN":["2231-4040","0976-2094"],"issn-type":[{"value":"2231-4040","type":"print"},{"value":"0976-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}