{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:09Z","timestamp":1787169729264,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Biofilm formation has become a serious health and environmental problem. Mushrooms are now considered a valuable source of bioactive compounds with antimicrobial properties. The lion's mane mushroom (\n                      <jats:italic toggle=\"yes\">Hericium erinaceus<\/jats:italic>\n                      [HE]) has been used as an antimicrobial for ulcers and gastritis in East Asian countries. However, studies on the antibiofilm activities of HE basidiome against biofilm-forming pathogenic bacteria and their bioactive compound profiles are still limited. The purpose of this study was to determine the antibiofilm activity of HE and to identify its phenolic compound profile. The HE inhibitory activities against bacterial growth and biofilm formation were performed against Pseudomonas aeruginosa,\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      Typhimurium, Proteus mirabilis, and Staphylococcus aureus. Remarkably,\n                      <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                      was the most susceptible bacteria to HE. The total phenolic content (TPC) of HE was 1652 \u00b1 1.06 \u00b5g\/ml, with protocatechuic acid and p-coumaric acid being the most abundant phenolic compounds as determined by high-performance liquid chromatography-mass spectrophotometry (HPLC-MS). This research highlights the possibility of HE as an antibiofilm agent that can be developed as a nutraceutical and natural food preservative.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/japtr.japtr_1_22","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T06:27:07Z","timestamp":1649226427000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Antibiofilm activity and bioactive phenolic compounds of ethanol extract from the Hericium erinaceus basidiome"],"prefix":"10.4103","volume":"13","author":[{"given":"Sari","family":"Darmasiwi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaovapa","family":"Aramsirirujiwet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingorn","family":"Kimkong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240903","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13020-019-0232-2","article-title":"Developing natural products as potential anti-biofilm agents","volume":"14","author":"Lu","year":"2019","journal-title":"Chin Med"},{"key":"R2-7-20240903","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.lwt.2009.12.008","article-title":"A review of current and emergent biofilm control strategies","volume":"43","author":"Sim\u00f5es","year":"2010","journal-title":"LWT"},{"key":"R3-7-20240903","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/08927014.2016.1208183","article-title":"Anti-biofilm potential of phenolic acids: The influence of environmental pH and intrinsic physico-chemical properties","volume":"32","author":"Silva","year":"2016","journal-title":"Biofouling"},{"key":"R4-7-20240903","doi-asserted-by":"crossref","first-page":"566325","DOI":"10.3389\/fmicb.2020.566325","article-title":"Natural anti-biofilm agents: Strategies to control biofilm-forming pathogens","volume":"11","author":"Mishra","year":"2020","journal-title":"Front Microbiol"},{"key":"R5-7-20240903","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/pathogens3030667","article-title":"Wild mushroom extracts as inhibitors of bacterial biofilm formation","volume":"3","author":"Alves","year":"2014","journal-title":"Pathogens"},{"key":"R6-7-20240903","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1615\/IntJMedMushrooms.2019030874","article-title":"Antioxidant, anticancer, antimicrobial, and antibiofilm properties of the culinary-medicinal fairy ring mushroom, Marasmius oreades (Agaricomycetes)","volume":"21","author":"Shomali","year":"2019","journal-title":"Int J Med Mushrooms"},{"key":"R7-7-20240903","doi-asserted-by":"crossref","first-page":"E963","DOI":"10.3390\/molecules25040963","article-title":"Discovery of antifungal and biofilm preventative compounds from Mycelial cultures of a unique North American Hericium sp.fungus","volume":"25","author":"Song","year":"2020","journal-title":"Molecules"},{"key":"R8-7-20240903","first-page":"1","article-title":"Biology, cultivation, and medicinal functions of the mushroom Hericium erinaceum","volume":"50","author":"Sokol","year":"2015","journal-title":"Acta Mycol"},{"key":"R9-7-20240903","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jep.2015.09.004","article-title":"Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus","volume":"183","author":"Liu","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"R10-7-20240903","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.lwt.2019.03.017","article-title":"Bio compounds of edible mushrooms: In vitro antioxidant and antimicrobial activities","volume":"107","author":"Bach","year":"2019","journal-title":"LWT"},{"key":"R11-7-20240903","first-page":"47","article-title":"Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.: Fr.) 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