{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:41:48Z","timestamp":1786725708429,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Rhododendron lowndesii<\/jats:italic>\n                    Davidian is an endemic medicinal plant of Nepal found in an altitude range of 3000\u20134100 m. This study investigates the phytochemical composition and bioactivities of its methanolic extract. The aerial part of the plant was extracted through methanol maceration to achieve 31.50% \u00b1 0.92% yield. Qualitative and quantitative phytochemical analysis of the extract revealed the presence of alkaloids, flavonoids, phenols, steroids, terpenoids, coumarins, and carbohydrates, with a total phenolic content of 175.63 \u00b1 1.37 mg GAE\/g and total flavonoid content (TFC) of 1090.36 \u00b1 2.29 mgQE\/g. Antioxidant activity assay of the extract suggested its strong radical scavenging activity through DPPH (IC\n                    <jats:sub>50<\/jats:sub>\n                    :19.46 \u00b1 1.85 \u00b5g\/mL) and ABST is 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays (IC\n                    <jats:sub>50:<\/jats:sub>\n                    13.4 \u00b1 0.20 \u00b5g\/mL). Antibacterial activity as determined by the disc diffusion method, showed significant effect against\n                    <jats:italic toggle=\"yes\">Bacillus subtilis<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (minimum inhibitory concentration: 312.5\u20131250 \u00b5g\/mL) but limited efficacy against\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    . High-resolution liquid chromatography-mass spectrometry identified pharmacologically significant compounds, including zapotin and cepharanthine. These findings suggest that\n                    <jats:italic toggle=\"yes\">R. lowndesii<\/jats:italic>\n                    has rich phytochemical profile and bioactivity; this supports its potential as a medicinal plant and need of its pharmacological research.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_235_25","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:00:15Z","timestamp":1778342415000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive potential of Rhododendron lowndesii: Extraction, antioxidant analysis, antimicrobial assay, and Liquid Chromatography-mass Spectrometry profiling"],"prefix":"10.4103","volume":"17","author":[{"given":"Anup","family":"Luitel","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal"},{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal"},{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit Mohan","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal"},{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwinee Kumar","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal"},{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niru","family":"Thapa","sequence":"additional","affiliation":[{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manika","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Modern Technical College, Pokhara University, Lekhnath, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh Datt","family":"Joshi","sequence":"additional","affiliation":[{"name":"Environment and Climate Change Section, Ministry of Forest and Environment, Pokhara, Gandaki Province, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirankumar","family":"Hullatti","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Sagar College of Pharmacy, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardan","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Organic Farming and Natural Product Research Center, Kathmandu University, Dhulikhel, Nepal"},{"name":"Department of Biotechnology, Kathmandu University, Dhulikhel, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"issue":"4","key":"R1-20260511","article-title":"A Gardener's Dwarf Rhododendrons","volume":"38","author":"Blake","year":"1984","journal-title":"Journal of the American Rhododendron Society."},{"key":"R2-20260511","first-page":"e34911","article-title":"Climatic variables determining Rhododendron sister taxa 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