{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:25:44Z","timestamp":1787765144441,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    The Suk-Saiyasna remedy, an herbal treatment, was historically used but ceased due to its cannabis content. After a relaxation of drug control laws in Thailand, its use re-emerged. This study examines the Suk-Saiyasna remedy\u2019s impact on rodent behavior and its receptor effects. This study was conducted to assess the sedative-like effects of the remedy on mice. The mice were divided into groups receiving 0.6, 3, 30, and 60 mg\/kg extracts, with negative controls for comparison. We also investigated the impact on receptors, utilizing negative controls and pretreatment with receptor blockers, followed by either a negative control or a 60 mg\/kg extract. Furthermore, this study investigated the behavioral aspects of mice, including anxiolytic effects, antidepressant-like effects, and motor coordination, utilizing the elevated plus-maze, open-field, and rotarod performance tests. The Suk-Saiyasna remedy (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05) decreased significantly in the latent period and increased sleeping time in the treated groups. Moreover, the Suk-Saiyasna remedy also showed efficacy in reaction to GABAA receptors and cannabinoid CB1 receptors (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). In addition, positive effects were observed regarding the animal behavior in the arena, as the animal activity, behavior, and muscle coordination were reduced (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). The Suk-Saiyasna remedy may be involved in a sedative\u2013hypnotic-like effect in rodents under normal conditions through the modulation of GABAergic neurons and induction of the cannabinoid CB1 receptor mechanism.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_355_23","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:00:24Z","timestamp":1705546824000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["The interaction of Suk-Saiyasna remedy with GABAA and CB1 receptor-targeting drugs: Enhancing hypnotic and sedative effects in in vivo models"],"prefix":"10.4103","volume":"15","author":[{"given":"Watchara","family":"Damjuti","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worathat","family":"Thitikornpong","sequence":"additional","affiliation":[{"name":"Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand"},{"name":"Centre of Excellence in DNA Barcoding of Thai Medicinal Plants, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinsamut","family":"Saengow","sequence":"additional","affiliation":[{"name":"Department of Animal Production Technology and Animal Health Science, Faculty of Agricultural Technology, Rajamangala University of Technology Thanyaburi, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanundorn","family":"Thanusuwannasak","sequence":"additional","affiliation":[{"name":"Chulalongkorn University Drugs and Health Product Innovation Promotion Centre, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanes","family":"Fuangfoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Rangsit University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurairat","family":"Boonruab","sequence":"additional","affiliation":[{"name":"Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"R1-20240903","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02861426","article-title":"The origin and use of cannabis in eastern asia linguistic-cultural implications","volume":"28","author":"Li","year":"1974","journal-title":"Econ Bot"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S1516-44462006000200015","article-title":"History of cannabis as a medicine: A review","volume":"28","author":"Zuardi","year":"2006","journal-title":"Braz J Psychiatry"},{"key":"R3-20240903","first-page":"27","article-title":"Announcement of the Ministry of Public Health: Prescribing Formulas for Narcotics of Category V Containing Cannabis Containing Compounds that can be Consumed for Medicinal Purposes or Research Studies","volume":"136","year":"2020","journal-title":"Gov Gaz"},{"key":"R4-20240903","year":"2014","journal-title":"Office of Information and Evaluation;Ministry of Public Health, Department for Development of Thai Traditional and Alternative Medicine. 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