{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:23:12Z","timestamp":1787746992847,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    A rising worldwide health concern, inflammatory bowel disease is linked to western-style diets that damage intestinal barrier integrity, change gut microbiota, and increase colonic inflammation. In contrast, inulin and glucomannan enhance short-chain fatty acid production and preserve mucosal structure, suggesting a protective role against diet-induced colonic inflammation. This study aimed to investigate whether combined inulin and glucomannan supplementation prevents western diet-induced colonic inflammation by modulating intestinal barrier function and colonic inflammatory cytokine profiles. Over 8 weeks, elicited by a high-fat, high-sucrose (HFHS) diet, colonic inflammation in mice as a model was utilized in a preventative experimental investigation. Mice received an HFHS diet with supplementation of inulin, glucomannan, or their combination. Colonic histopathology was evaluated, and interleukin 6 (IL-6) and IL-10 levels were assessed using immunohistochemistry. Statistical analyses included one-way analysis of variance with appropriate\n                    <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                    tests, covariate-adjusted analyses controlling for caloric intake, and correlation analyses between histological and inflammatory parameters. Fiber supplementation reduced HFHS-induced colonic inflammation severity, crypt shortening, and mucosal thinning without affecting caloric intake. While colonic inflammation severity linked favorably with IL-6 and inversely with IL-10 and mucosal integrity, combined inulin\u2013glucomannan supplementation provided the lowest IL-6\/IL-10 ratio along with uniquely elevated IL-10 expression, indicating better immunomodulatory effects. Soluble fiber supplementation prevents HFHS-induced colonic inflammation by preserving mucosal architecture and restoring inflammatory cytokine balance, with combined inulin and glucomannan providing additive immunoprotective benefits.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_36_26","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:00:09Z","timestamp":1786546809000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Combined inulin and glucomannan modulate colonic cytokine balance and mucosal barrier function in a western diet-induced colonic inflammation mouse model"],"prefix":"10.4103","volume":"17","author":[{"given":"Bernadette Dian","family":"Novita","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Christian","family":"Angkawijaya","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Gede Putu Adhi","family":"Wedharga","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suciatuz Zinanir","family":"Rohman","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand Wiliam","family":"Jaya","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Widarma","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Timothy","family":"Abraham","sequence":"additional","affiliation":[{"name":"Undergraduate Program, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Lingkan","family":"Parengkuan","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi Pramono","family":"Hendrata","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Pharmacology, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendy","family":"Wijaya","sequence":"additional","affiliation":[{"name":"Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudy","family":"Tjahjono","sequence":"additional","affiliation":[{"name":"Biomedical Laboratory, Faculty of Pharmacy, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sianty","family":"Dewi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niluh","family":"Suwasanti","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Faculty of Medicine, Widya Mandala Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endang Isbandiati","family":"Soediono","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Kalisari Selatan, Pakuwon City, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suryo","family":"Kuncorojakti","sequence":"additional","affiliation":[{"name":"Research Center for Vaccine Technology and Development, Institute of Tropical Disease, Airlangga University, Surabaya, 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oxidative stress in the colon","volume":"317","author":"Li","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R4-20260826","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3390\/nu10060761","article-title":"High-glucose or -fructose diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change","volume":"10","author":"Do","year":"2018","journal-title":"Nutrients"},{"key":"R5-20260826","doi-asserted-by":"crossref","first-page":"108903","DOI":"10.1016\/j.jnutbio.2021.108903","article-title":"Ten-week high fat and high sugar diets in mice alter gut-brain axis cytokines in a sex-dependent manner","volume":"100","author":"Church","year":"2022","journal-title":"J Nutr Biochem"},{"key":"R6-20260826","doi-asserted-by":"crossref","first-page":"456","DOI":"10.18585\/inabj.v17i5.3807","article-title":"Modified high-fat high-sucrose diet promotes obesity and alters colonic 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