{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:26:40Z","timestamp":1786728400558,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>BaiYangJie (BYJ) is a terrestrial perennial plant commonly used as a Dai medicine and has therapeutic effects on liver and kidney diseases. Cisplatin (CP), a chemotherapy drug, has good therapeutic effects but causes many side effects, including nephrotoxicity. This article investigated the toxicology of the methanol extract of BYJ (ME-BYJ) and its protective effect on CP-induced acute kidney injury (AKI) through pharmacological experiments. The results showed that the treated mice had no toxicological symptoms and no anatomical, physiological, or histological abnormalities. The BYJ-high-dose group showed significantly attenuated CP-induced AKI. It is concluded that ME-BYJ has the most significant protective effect on AKI at a dose of 8 g\/kg and BYJ was not toxic.<\/jats:p>","DOI":"10.4103\/japtr.japtr_467_23","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T06:03:43Z","timestamp":1721628223000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the methanol extract of BaiYangJie: Toxicology and protective effect against acute kidney injury"],"prefix":"10.4103","volume":"15","author":[{"given":"Jiaxin","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China"},{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"The ICU of People\u2019s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Jinghong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Jinghong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China"},{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Jinghong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Ren","sequence":"additional","affiliation":[{"name":"Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Branch, China"},{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Jinghong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Integrated Traditional Chinese and Western Clinical, Beijing University of Chinese Medicine DongFang College, Cangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"R1-20260507","first-page":"2020","article-title":"Cordyceps cicadae mycelia ameliorate cisplatin-induced acute kidney injury by suppressing the TLR4\/NF-\u03baB\/MAPK and activating the HO-1\/Nrf2 and sirt-1\/AMPK pathways in mice","author":"Deng","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"R2-20260507","first-page":"2020","article-title":"Pretreatment with roxadustat (FG-4592) attenuates folic acid-induced kidney injury through antiferroptosis via Akt\/GSK-3\u03b2\/Nrf2 pathway","author":"Li","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1515\/CCLM.2011.664","article-title":"New biomarkers for acute renal injury","volume":"49","author":"Soni","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"941.","DOI":"10.3390\/molecules27030941","article-title":"Nephroprotective Effects of Alhagi camelorum against cisplatin-induced nephrotoxicity in albino wistar Rats","volume":"27","author":"Iqbal","year":"2022","journal-title":"Molecules"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/14786419.2017.1332606","article-title":"Phenanthrenes from Arundina graminifolia and in vitro evaluation of their antibacterial and anti-haemolytic properties","volume":"32","author":"Yan","year":"2018","journal-title":"Nat Prod Res"},{"issue":"10","key":"R6-20260507","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1021\/np400379u","article-title":"Cytotoxic Deoxybenzoins and Diphenylethylenes from Arundina graminifolia[J]","volume":"76","author":"Hu","year":"2013","journal-title":"Journal of Natural Products"},{"key":"R7-20260507","first-page":"66","article-title":"Research progress on Dai medicine Arundina graminifolia","volume":"30","author":"Zhu","year":"2021","journal-title":"Chin J Ethnomed Ethnopharm"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"153555.","DOI":"10.1016\/j.phymed.2021.153555","article-title":"Kaempferol alleviates calcium oxalate crystal-induced renal injury and crystal deposition via regulation of the AR\/NOX2 signaling pathway","volume":"86","author":"Yuan","year":"2021","journal-title":"Phytomedicine"},{"key":"R9-20260507","first-page":"1","article-title":"Kaempferol reverses acute kidney injury in septic model by inhibiting NF-\u03ba B\/AKT signaling pathway","volume":"2023","author":"Chen","year":"2023","journal-title":"J Food Biochem"},{"key":"R10-20260507","doi-asserted-by":"crossref","first-page":"56.","DOI":"10.4103\/phrev.phrev_47_17","article-title":"Exploring the mechanisms of cytotoxic and anti-inflammatory property of andrographolide and its derivatives","volume":"12","author":"Raghavan","year":"2018","journal-title":"Pharmacogn Rev"},{"key":"R11-20260507","doi-asserted-by":"crossref","first-page":"2462.","DOI":"10.3390\/molecules27082462","article-title":"Phenolic acids and flavonoids in acetonic extract from quince (Cydonia oblonga mill.): Nutraceuticals with antioxidant and anti-inflammatory potential","volume":"27","author":"Herrera-Rocha","year":"2022","journal-title":"Molecules"},{"key":"R12-20260507","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2016.07.003","article-title":"Protective role of apigenin in cisplatin-induced renal injury[J]","volume":"789","author":"He","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"R13-20260507","first-page":"4698","article-title":"The protective effect and mechanism of dehydrogenated Tetradium ruticarpum on gastric mucosa of experimental gastric ulcer rats","volume":"51","author":"Wan","year":"2020","journal-title":"Chin Tradit Herb Drugs"}],"container-title":["Journal of Advanced Pharmaceutical Technology &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JAPTR.JAPTR_467_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:33Z","timestamp":1786724793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JAPTR.JAPTR_467_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/japtr.japtr_467_23","relation":{},"ISSN":["2231-4040","0976-2094"],"issn-type":[{"value":"2231-4040","type":"print"},{"value":"0976-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-10-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}