{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:25Z","timestamp":1786649965013,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Cordyline fruticosa<\/jats:italic>\n                    <jats:italic toggle=\"yes\">(L.) A. Chev. (CF)<\/jats:italic>\n                    is an ornamental plant known for its therapeutic properties, particularly its antimicrobial activity. This study attempted to identify bioactive compounds in the\n                    <jats:italic toggle=\"yes\">CF<\/jats:italic>\n                    leaf extract and assess their antibacterial and antifungal efficacy against\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    , which are key contributors to early childhood caries (ECC).\n                    <jats:italic toggle=\"yes\">CF<\/jats:italic>\n                    leaves were extracted using the maceration technique with 70% methanol. Phytochemical and gas chromatography-mass spectrometry (GC-MS) screening were performed to identify secondary metabolites and chemical compounds.\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    were isolated from supragingival plaque samples of paediatric patients with severe ECC. The minimum inhibitory concentration (MIC) was determined through serial dilution and ELISA spectrophotometry. Phytochemical screening verified the existence of phenolic compounds, flavonoids, saponins, triterpenoids, and alkaloids. GC-MS identified 17 chemical compounds. The MIC was 6.25% for\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    and 1.56% for\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    . The extract exhibited significant antimicrobial activity, with a stronger inhibitory effect against\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    than\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    . The\n                    <jats:italic toggle=\"yes\">CF<\/jats:italic>\n                    leaf extract demonstrates antibacterial and antifungal potential and may serve as a cariogenic antimicrobial agent. Further toxicological studies are needed to confirm its safety for clinical applications.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_76_25","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T08:00:32Z","timestamp":1754726432000},"page":"156-162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Identification of bioactive compounds in Cordyline fruticosa (L.) A. Chev. leaf extract and its antimicrobial activity against cariogenic microorganisms"],"prefix":"10.4103","volume":"16","author":[{"given":"Likky Tiara","family":"Alphianti","sequence":"first","affiliation":[{"name":"Oral Science Research Centre, Faculty of Dentistry, Universitas Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endang Winiati","family":"Bachtiar","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia and Oral Science Research Centre, Faculty of Dentistry, Universitas Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi Fatma","family":"Suniarti","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia and Oral Science Research Centre, Faculty of Dentistry, Universitas Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fauziah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40816-019-0109-z","article-title":"Anti-diarrheal activity and brine shrimp lethality bioassay of methanolic extract of Cordyline fruticosa (L.) 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