{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:28:35Z","timestamp":1787776115222,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Rhizophora stylosa<\/jats:italic>\n                    Griff. roots contain bioactive metabolites and therapeutic potential. This study measured the antioxidants, toxicity and cytotoxicity from its dichloromethane extract and four derived fractions (RSD 1\u20134). The extracts showed strong antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 7.50 ppm) and toxicity (LC\n                    <jats:sub>50<\/jats:sub>\n                    = 31.92 ppm). Evaluation of each fraction showed that RSD 2 had the highest activity for antioxidant bioactivity with IC\n                    <jats:sub>50<\/jats:sub>\n                    of 45.40 ppm and toxicity with LC\n                    <jats:sub>50<\/jats:sub>\n                    value of 332.48 ppm. Cytotoxicity against MCF-7 cells showed that RSD 3 had the stronger effect, followed by RSD 2 with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 225.50 ppm and 155.90 ppm, respectively. Statistical analysis confirmed that differences in antioxidant and toxicity activities among extract and fractions were significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05), whereas cytotoxic activity differences were not statistically significant. Gas chromatography\u2013mass spectrometry analysis of RSD 2 identified stigmasta-3,5-diene, \u03b1-amyrin, and lupeol as major components and potentially responsible for the bioactivities. In summary, dichloromethane root extract of\n                    <jats:italic toggle=\"yes\">R. stylosa<\/jats:italic>\n                    Griff. may serve as phytomedicines for breast cancer.\n                  <\/jats:p>","DOI":"10.4103\/japtr.japtr_89_25","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:02:20Z","timestamp":1760936540000},"page":"177-182","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant, toxicity, and cytotoxicity activities from dichloromethane root extract and fraction of Rhizophora stylosa Griff"],"prefix":"10.4103","volume":"16","author":[{"given":"Nurdin","family":"Saidi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binawati","family":"Ginting","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustanir","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murniana","family":"Murniana","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnia","family":"Purnama","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cantika Dwi","family":"Riski","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/cells9030563","article-title":"Recent progress of stem cell therapy in cancer treatment: Molecular mechanisms and potential applications","volume":"9","author":"Chu","year":"2020","journal-title":"Cells"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"115781","DOI":"10.1016\/j.biopha.2023.115781","article-title":"The effect of chemotherapy and radiotherapy on stem cells and wound healing. 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