{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:59:11Z","timestamp":1788454751633,"version":"build-2803163510"},"reference-count":10,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Vitiligo is a multifactorial acquired disorder clinically characterized by amelanotic lesions on the skin, due to destruction of melanocytes. The course of vitiligo is unpredictable. Vitiligo causes significant psychological impact and cosmetic disfigurement. Treatment of vitiligo is challenging and requires a multidisciplinary approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>A prospective comparative interventional study was carried out from October 2018 to March 2020. The study enrolled 60 stable vitiligo patients divided into groups A and B. Group A (30 patients) was treated with both fractional CO<jats:sub>2<\/jats:sub> laser and autologous platelet-rich plasma (PRP) injection. Group B (30 patients) was treated with fractional CO<jats:sub>2<\/jats:sub> laser alone. A total of four sessions were conducted in each group at 1-month interval along with photographic assessment. Final assessment was done 1 month after the completion of four sessions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In group A, the median values of repigmentation and visual-analog score (VAS) were 3 and 7, and in group B, the median values of repigmentation and VAS were 1 and 2, respectively. Lesions over the trunk showed the best response followed by face and extremities lesions. Acral lesions showed the least response.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>A combination of fractional CO<jats:sub>2<\/jats:sub> laser and PRP is superior to fractional CO<jats:sub>2<\/jats:sub> laser alone in the treatment of stable vitiligo.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/jcas.jcas_103_22","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T11:20:05Z","timestamp":1700738405000},"page":"186-191","source":"Crossref","is-referenced-by-count":6,"title":["A comparative study to evaluate the efficacy of fractional CO2 laser + PRP vs. fractional CO2 laser alone in patients with vitiligo"],"prefix":"10.25259","volume":"16","author":[{"given":"Shweta","family":"Ahlawat","sequence":"first","affiliation":[{"name":"Department of Dermatology, JLN Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Kothiwala","sequence":"additional","affiliation":[{"name":"Department of Dermatology, JLN Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Meherda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, JLN Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"CIT0001-20231123","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/ijd.14286","article-title":"Use of platelet-rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: A double-blind randomized controlled trial","volume":"58","author":"Parambath","year":"2019","journal-title":"Int J Dermatol"},{"key":"CIT0002-20231123","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0190-9622(88)70168-1","article-title":"Biology of hypopigmentation","volume":"19","author":"Bolognia","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"CIT0003-20231123","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised classification\/nomenclature of vitiligo and related issues: The Vitiligo Global Issues Consensus Conference","volume":"25","author":"Ezzedine","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"CIT0004-20231123","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1755-148X.2011.00838.x","article-title":"Koebner\u2019s phenomenon in vitiligo: European position paper","volume":"24","author":"van Geel","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"CIT0005-20231123","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.coi.2013.10.010","article-title":"Innate immune mechanisms in vitiligo: Danger from within","volume":"25","author":"Richmond","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"CIT0006-20231123","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/dth.12202","article-title":"Triple combination treatment with fractional CO2 laser plus topical betamethasone solution and narrowband ultraviolet B for refractory vitiligo: A prospective, randomized half-body, comparative study","volume":"28","author":"Li","year":"2015","journal-title":"Dermatol Ther"},{"key":"CIT0007-20231123","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1055\/s-0039-1698338","article-title":"Platelet rich plasma: Myth or reality?","volume":"1","author":"Wang","year":"2007","journal-title":"Eur J Dent"},{"key":"CIT0008-20231123","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaad.2019.04.037","article-title":"Platelet-rich plasma and its utility in medical dermatology: A systematic review","volume":"81","author":"Hesseler","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"CIT0009-20231123","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/jocd.12397","article-title":"Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial","volume":"17","author":"Abdelghani","year":"2018","journal-title":"J Cosmet Dermatol"},{"key":"CIT0010-20231123","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2147\/CCID.S178817","article-title":"Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: A comparative study","volume":"11","author":"Kadry","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["Journal of Cutaneous and Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/JCAS.JCAS_103_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:16:57Z","timestamp":1725088617000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcasonline.com\/a-comparative-study-to-evaluate-the-efficacy-of-fractional-co2-laser-prp-vs-fractional-co2-laser-alone-in-patients-with-vitiligo\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jcas.jcas_103_22","relation":{},"ISSN":["0974-2077"],"issn-type":[{"value":"0974-2077","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}