{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:04:41Z","timestamp":1776470681668,"version":"3.51.2"},"reference-count":6,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Filler complications have a wide array of presentations including early and late manifestations. A rare late complication is the foreign body granuloma or granulomatous foreign body reaction. We present a case of giant foreign body granulomas developing 7 years after polymethylmethacrylate (PMMA) filler injection. The patient had an excellent response to a single intralesional injection of triamcinolone acetonide and 5-fluorouracil. The unique opportunity to have pretreatment and posttreatment magnetic resonance imaging (MRI) allows for appreciation of the multidirectional expansion of these granulomas as well as the response in this case. Updated treatment recommendations based on the literature review support the use of oral antibiotics, oral steroids, and intralesional therapies. Surgical excision is reserved as an absolute last resort due to potential complications.<\/jats:p>","DOI":"10.4103\/jcas.jcas_194_20","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T15:50:54Z","timestamp":1687621854000},"page":"256-258","source":"Crossref","is-referenced-by-count":10,"title":["Giant PMMA foreign body granulomas with imaging"],"prefix":"10.25259","volume":"16","author":[{"given":"Sunthosh","family":"Sivam","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Mackay","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton","family":"Humphrey","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J David","family":"Kriet","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"key":"CIT0001-20231123","doi-asserted-by":"crossref","first-page":"196S","DOI":"10.1097\/PRS.0000000000001760","article-title":"Understanding, avoiding, and managing severe filler complications","volume":"136","author":"Rzany","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"CIT0002-20231123","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1097\/PRS.0b013e31816b1385","article-title":"Complications after polymethylmethacrylate injections: report of 32 cases","volume":"121","author":"Salles","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"CIT0003-20231123","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5999\/aps.2015.42.2.232","article-title":"Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment","volume":"42","author":"Lee","year":"2015","journal-title":"Arch Plast Surg"},{"key":"CIT0004-20231123","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/14764172.2015.1114642","article-title":"Delayed granulomatous reactions to facial cosmetic injections of polymethylmethacrylate microspheres and liquid injectable silicone: a case series","volume":"18","author":"Friedmann","year":"2016","journal-title":"J Cosmet Laser Ther"},{"key":"CIT0005-20231123","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1111\/j.1524-4725.2009.01347.x","article-title":"Electron microscopic documentation of late changes in permanent fillers and clinical management of granulomas in affected patients","volume":"35","author":"Wiest","year":"2009","journal-title":"Dermatol Surg"},{"key":"CIT0006-20231123","first-page":"1079","article-title":"Adverse granulomatous reaction to artecoll treated by instralesional 5-fluorouracil and triamcinolone","volume":"32","author":"Conejo-Mir","year":"2006","journal-title":"Injections"}],"container-title":["Journal of Cutaneous and Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/JCAS.JCAS_194_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:17:06Z","timestamp":1725088626000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcasonline.com\/giant-pmma-foreign-body-granulomas-with-imaging\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jcas.jcas_194_20","relation":{},"ISSN":["0974-2077"],"issn-type":[{"value":"0974-2077","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}