{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:19:20Z","timestamp":1784110760170,"version":"3.55.0"},"reference-count":21,"publisher":"Scientific Scholar","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Alopecia areata (AA) is a non-scarring alopecia of chronic autoimmune etiology with heterogenous severity against the anagen hair follicle over the scalp, beard, or any part of the body and is associated with a significant psychological morbidity in the mental status of the patients leading the patients to seek treatment for cosmetic reasons. The management of AA is very unpredictable and is associated with various cosmetic adverse effects. This study aimed at comparing the efficacy and safety of a novel procedure of laser-assisted drug delivery system of steroids with the first-line procedure of intralesional steroids (ILS) for the treatment of patchy AA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims and Objectives:<\/jats:title>\n            <jats:p>To assess and compare the efficacy and safety of fractional CO<jats:sub>2<\/jats:sub> laser in combination with topical triamcinolone acetonide aqueous solution and intralesional triamcinolone acetonide as a monotherapy and in the treatment of AA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>A total of 60 patchy AA patients were included in this study. Patients were randomized into two equal groups: Group A and Group B with 30 patients in each group using a computer-generated block randomization. Patients in Group A received fractional CO<jats:sub>2<\/jats:sub> laser with topical triamcinolone acetonide aqueous solution and Group B received ILS. Both groups received treatment for five settings with each setting a gap of 3 weeks. The efficacy and safety of treatment modalities in both groups were assessed using global photograph assessment (GPA)-scale, lesional area density score percentage of improvement (LAD score improvement %), visual discomfort scale (VDS), visual analogue scale, and documentation of adverse effects in each setting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Efficacy of treatment modality-assessed using means score of GPA-scale and LAD score improvement % suggests quicker results to patients in Group B in initial settings but drastic improvement happens to patients in Group A in subsequent settings. At the end of 5th setting, GPA-scale and LAD score improvement % suggest maximum efficacy in patients in Group A and they are statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>-value &lt; 0.001). The mean VDS in both groups suggests maximum discomfort in Group A, yet the patient satisfaction at the end of 5th setting was maximum with patients in Group A and they are statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>-value &lt; 0.001). Cosmetic notable adverse effect of atrophy of skin was documented in 30% of patients in Group B.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>This study showed that fractional CO<jats:sub>2<\/jats:sub> laser with topical triamcinolone acetonide is a better treatment modality than the intralesional triamcinolone acetonide for the treatment of AA with respect to efficacy, safety, and adverse events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/jcas.jcas_31_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T16:05:38Z","timestamp":1713283538000},"page":"34-40","source":"Crossref","is-referenced-by-count":8,"title":["A comparative study of fractional CO2 laser with topical triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of alopecia areata"],"prefix":"10.25259","volume":"17","author":[{"given":"Harish","family":"Prasanna","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Leprosy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajashekar Talari","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprosy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Kumar","family":"Kuppuswamy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprosy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanumanthayya","family":"Keloji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprosy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavithra Thotta","family":"Ravikumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprosy, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"CIT0001-20240419","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12016-021-08883-0","article-title":"Alopecia areata: An update on etiopathogenesis, diagnosis, and management","volume":"61","author":"Zhou","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"CIT0002-20240419","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10238-020-00673-w","article-title":"Alopecia areata: A review on diagnosis, immunological etiopathogenesis and treatment options","volume":"21","author":"Sterkens","year":"2021","journal-title":"Clin Exp Med"},{"key":"CIT0003-20240419","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.det.2021.03.005","article-title":"Alopecia areata: New treatment options including janus kinase inhibitors","volume":"39","author":"Zheng","year":"2021","journal-title":"Dermatol Clin"},{"key":"CIT0004-20240419","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2018.12.001","article-title":"Alopecia areata: A multifactorial autoimmune condition","volume":"98","author":"Simakou","year":"2019","journal-title":"J Autoimmun"},{"key":"CIT0005-20240419","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaad.2017.04.1142","article-title":"Alopecia areata: An appraisal of new treatment approaches and overview of current therapies","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J Am Acad 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(Heidelb)"},{"key":"CIT0009-20240419","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jaad.2017.10.048","article-title":"Objective outcome measures: Collecting meaningful data on alopecia areata","volume":"79","author":"Olsen","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"CIT0010-20240419","first-page":"404","article-title":"Alopecia areata. Current situation and perspectives","volume":"115","author":"Ju\u00e1rez-Rend\u00f3n","year":"2017","journal-title":"Arch Argent Pediatr"},{"key":"CIT0011-20240419","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3390\/ijms23031038","article-title":"Lifestyle factors involved in the pathogenesis of alopecia areata","volume":"23","author":"Minokawa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"CIT0012-20240419","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"CIT0013-20240419","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2017.04.1141","article-title":"Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"CIT0014-20240419","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jaad.2018.01.048","article-title":"Alopecia areata is associated with impaired health-related quality of life: A survey of affected adults and children and their families","volume":"79","author":"Liu","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"CIT0015-20240419","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1365-4632.2009.04230.x","article-title":"Treatment of alopecia areata with fractional photothermolysis laser","volume":"49","author":"Yoo","year":"2010","journal-title":"Int J Dermatol"},{"key":"CIT0016-20240419","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/14764172.2013.764436","article-title":"Clinical effects of non-ablative and ablative fractional lasers on various hair disorders: A case series of 17 patients","volume":"15","author":"Cho","year":"2013","journal-title":"J Cosmet Laser Ther"},{"key":"CIT0017-20240419","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/lsm.22358","article-title":"Hair regrowth through wound healing process after ablative fractional laser treatment in a murine model","volume":"47","author":"Bae","year":"2015","journal-title":"Lasers Surg Med"},{"key":"CIT0018-20240419","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/JCAS.JCAS_96_18","article-title":"fractional carbon dioxide laser in combination with topical corticosteroid application in resistant alopecia areata: A case series","volume":"11","author":"Majid","year":"2018","journal-title":"J Cutan Aesthet Surg"},{"key":"CIT0019-20240419","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00403-022-02393-5","article-title":"Evaluation of fractional carbon dioxide laser alone versus its combination with betamethasone valerate in treatment of alopecia areata, a clinical and dermoscopic study","volume":"315","author":"Halim","year":"2023","journal-title":"Arch Dermatol Res"},{"key":"CIT0020-20240419","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/jewd.jewd_63_20","article-title":"Fractional carbon dioxide laser-assisted topical steroid delivery versus intralesional steroid in the treatment of alopecia areata","volume":"18","author":"Soror","year":"2021","journal-title":"J Egypt Womens Dermatol Soc"},{"key":"CIT0021-20240419","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jaad.2019.11.066","article-title":"Efficacy of different concentrations of intralesional triamcinolone acetonide for alopecia areata: A systematic review and meta-analysis","volume":"82","author":"Yee","year":"2020","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of Cutaneous and Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/JCAS.JCAS_31_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:17:30Z","timestamp":1725088650000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcasonline.com\/a-comparative-study-of-fractional-co2-laser-with-topical-triamcinolone-acetonide-versus-intralesional-triamcinolone-acetonide-in-the-treatment-of-alopecia-areata\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jcas.jcas_31_23","relation":{},"ISSN":["0974-2077"],"issn-type":[{"value":"0974-2077","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}