{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:33:32Z","timestamp":1769222012306,"version":"3.49.0"},"reference-count":28,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Keloids are less responsive to any single treatment modality; hence, there is a need for combination therapy that can yield satisfactory outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The present study assessed efficacy and safety of combination therapy\u2014surgical excision or cryotherapy and intralesional corticosteroids along with 5-fluorouracil [IL (S + 5-FU)] injection, followed by silicone gel sheet (SGS) under compression therapy in the treatment of keloids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>This was a retrospective, observational study comprising 21 clinically diagnosed keloid patients. All patients were treated with the stated combination therapy. Data about demographic, lesions, procedural characteristics, and treatment outcomes were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Of 21, 11 (52.4%) patients were treated with liquid nitrogen (LN<jats:sub>2<\/jats:sub>) cryotherapy, and 10 (47.6%) patients were treated with surgical excision. Mean age was 30.8\u2009\u00b1\u20097.6 (range: 14\u201344) years with slight male (52.4%) predominance. A mean surface area of keloid lesion was 96.8\u2009\u00b1\u2009170.5\u2009cm<jats:sup>3<\/jats:sup>. The most frequently involved site was auricle (8 [38.1%] patients). Patients received the following types of treatments: intralesional LN<jats:sub>2<\/jats:sub>cryotherapy (6 [28.6%]), intralesional excisional surgery (6 [28.6%]), surface LN<jats:sub>2<\/jats:sub>cryotherapy (5 [23.8%]), and extralesional excisional surgery (4 [19.0%]). Complications of recurrence (2 [9.5%]), secondary infections (2 [9.5%]), persistent postinflammatory hypopigmentation (1 [4.8%]), and atrophic scarring with postinflammatory hyperpigmentation (1 [4.8%]) were reported. After a study period of 2.5 years, 100% cure rate was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Combination therapy of surgical excision or cryotherapy and IL (S + 5-FU), followed by SGS under compression, was safe and effective in treating keloids.<\/jats:p><\/jats:sec>","DOI":"10.4103\/jcas.jcas_40_23","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T06:00:46Z","timestamp":1691128846000},"page":"85-93","source":"Crossref","is-referenced-by-count":6,"title":["Selective therapy (cryo or scalpel) combined with multimodal therapy for treating keloids"],"prefix":"10.25259","volume":"17","author":[{"given":"Sushil S","family":"Savant","sequence":"first","affiliation":[{"name":"The Humanitarian Clinic, Skin: Hair and Laser Centre, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish S","family":"Savant","sequence":"additional","affiliation":[{"name":"The 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