{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:37:34Z","timestamp":1787585854890,"version":"build-2736575974"},"reference-count":15,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Striae distensae are atrophic scars that are often cosmetically distressing. The efficacy of fractional carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser and platelet-rich plasma (PRP) in treating striae individually has been evaluated previously. However, not many studies described the combined efficacy of both.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims and Objectives:<\/jats:title>\n            <jats:p>The aim of this study was to compare the efficacy and safety of fractional CO<jats:sub>2<\/jats:sub> laser alone and in combination with PRP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>Twenty-four patients with striae presenting bilaterally in the abdomen, upper limbs, and lower limbs were included. PRP was prepared by double-spin method and cell count was done to ensure at least fourfold concentration of platelets. The patients were treated CO<jats:sub>2<\/jats:sub> laser on both sides and PRP on the left side along with laser, every month for three sessions. Digital photography and dermoscopy were done at baseline, every treatment session, and 6 months after treatment. Clinical improvement was assessed by comparing photographs and patient satisfaction before and after treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>All patients showed improvement on both sides. In CO<jats:sub>2<\/jats:sub>-laser-treated patients, responses in 6 patients (25%) were moderate, 14 (56%) were good, and 4 (16.6%) were excellent. In CO<jats:sub>2<\/jats:sub>-laser and PRP-treated patients, responses in 5 patients (20.8%) were moderate, 11 (45.8%) were good, and 8 (33.3%) were excellent. Hyperpigmentation was the most common side-effect seen (19 patients) on both sides, which resolved spontaneously by 6 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>These results support the use of ablative CO<jats:sub>2<\/jats:sub> fractional laser as effective and safe treatment modalities for striae. However, slightly better efficacy was noted with the addition of PRP.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/jcas.jcas_65_22","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T11:43:04Z","timestamp":1700739784000},"page":"178-185","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of fractional carbon dioxide laser versus fractional carbon dioxide laser with platelet-rich plasma in treatment of striae distensae in a tertiary care center: A comparative study"],"prefix":"10.25259","volume":"16","author":[{"given":"Shashikumar Basavapura","family":"Madegowda","sequence":"first","affiliation":[{"name":"Department of Dermatology, Mandya Institute of Medical Sciences (MIMS), Mandya, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish Muddanahalli","family":"Rajegowda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mandya Institute of Medical Sciences (MIMS), Mandya, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepadarshan","family":"Kalegowda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mandya Institute of Medical Sciences (MIMS), Mandya, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phani Halevoor","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mandya Institute of Medical Sciences (MIMS), Mandya, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha Mullagura","family":"Naidu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mandya Institute of Medical Sciences (MIMS), Mandya, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"CIT0001-20231123","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00403-013-1336-7","article-title":"A double-blind 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distensae","volume":"28","author":"Hern\u00e1ndez-P\u00e9rez","year":"2002","journal-title":"Dermatologic Surgery"},{"key":"CIT0012-20231123","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jaad.2017.02.048","article-title":"Therapeutic targets in the management of striae distensae: A systematic review","volume":"77","author":"Hague","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"CIT0013-20231123","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/14764172.2018.1525749","article-title":"Efficacy of fractional carbon dioxide laser versus microneedling in the treatment of striae distensae","volume":"21","author":"Soliman","year":"2019","journal-title":"J Cosmet Laser Ther"},{"key":"CIT0014-20231123","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/j.1524-4725.2010.01719.x","article-title":"Treatment of striae distensae using an ablative 10,600-nm carbon dioxide fractional laser: A retrospective review of 27 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