{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:47:42Z","timestamp":1776833262765,"version":"3.51.2"},"reference-count":12,"publisher":"Scientific Scholar","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCAS"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Acanthosis Nigricans (AN) is an acquired disorder of keratinization. It presents as hyperpigmentation, velvety texture of skin that can involve any part of the body including the face. Different topical, systemic therapies, or physical therapies including laser have been explored. However, there are not many randomized controlled studies for the majority of therapy alternatives besides lifestyle modifications and weight reduction.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The aim of this study was to compare the effectiveness of 15% trichloroacetic acid (TCA) and 35% glycolic acid (GA) peel for AN.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Forty participants were included and randomized into two groups. In groups A and B, peeling with 15% TCA and 35% GA was done, respectively. The effectiveness of each peel was assessed using changes in the Acanthosis Nigricans Area and Severity Index Score (ANASI) and Physician Assessment Score. Statistical analysis included Wilcoxon\u2013Mann\u2013Whitney test, Friedman test, and generalized estimating equations.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The overall change in ANASI over time was compared in the two groups using the generalized estimating equations method. A significant difference was observed in the trend of ANASI over time between the two groups (P<\/jats:italic> < 0.001). TCA peel group showed more change in ANASI as compared with GA peel group.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In our research, 15% TCA has a better efficacy when compared with 35% GA peel after three sessions of chemical peeling. We therefore recommend the use of 15% TCA peel in AN as a safe and effective treatment option. However, more comprehensive randomized control studies are required for supporting data.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcas.jcas_76_23","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T06:01:14Z","timestamp":1691128874000},"page":"94-99","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of 15% trichloroacetic acid peel versus 35% glycolic acid peel in acanthosis Nigricans: A randomized open-label study"],"prefix":"10.25259","volume":"17","author":[{"given":"Bharati","family":"Bharati","sequence":"first","affiliation":[{"name":"Department of Dermatology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taru","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibhu","family":"Mendiratta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"CIT0001-20240429","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/ijpd.IJPD_34_18","article-title":"Childhood acanthosis Nigricans","volume":"20","author":"Das","year":"2019","journal-title":"Indian J Paediatr Dermatol"},{"key":"CIT0002-20240429","first-page":"170","article-title":"To compare the efficacy and safety of trichloroacetic acid peel with topical tretinoin in the treatment of acanthosis Nigricans: A randomized controlled study","volume":"29","author":"Rajegowda","year":"2019","journal-title":"J Pak Assoc Dermatol"},{"key":"CIT0003-20240429","first-page":"159","article-title":"Topical tretinoin in acanthosis Nigricans","volume":"62","author":"Lahiri","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"CIT0004-20240429","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/09546634.2019.1708855","article-title":"The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis Nigricans","volume":"32","author":"Treesirichod","year":"2021","journal-title":"J Dermatol Treat"},{"key":"CIT0005-20240429","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/CCID.S137527","article-title":"Current treatment options for acanthosis Nigricans","volume":"11","author":"Patel","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"CIT0006-20240429","first-page":"884","article-title":"Comparison of metformin versus rosiglitazone in patients with acanthosis Nigricans: A pilot study","volume":"5","author":"Bellot-Rojas","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"CIT0007-20240429","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1111\/jocd.14731","article-title":"Treatment of acanthosis Nigricans with sequential salicylic acid\u2010mandelic acid combination peel and maintenance with glycolic acid\u2010urea combination cream: A retrospective pilot study","volume":"21","author":"Zeeshan","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"CIT0008-20240429","first-page":"1158","article-title":"Treatment of acanthosis Nigricans of the axillae using a long-pulsed (5-msec) alexandrite laser","volume":"30","author":"Rosenbach","year":"2004","journal-title":"Dermatol Surg"},{"key":"CIT0009-20240429","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10103-019-02944-9","article-title":"Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis Nigricans: A prospective, randomized, controlled trial","volume":"35","author":"Leerapongnan","year":"2020","journal-title":"Lasers Med Sci"},{"key":"CIT0010-20240429","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/jewd.jewd_65_20","article-title":"Use of a novel quantitative tool for evaluation of pseudo-acanthosis Nigricans: Acanthosis Nigricans area and severity index (ANASI)","volume":"18","author":"Zaki","year":"2021","journal-title":"J Egypt Women Dermatol Soc"},{"key":"CIT0011-20240429","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/09546634.2012.674194","article-title":"Using trichloroacetic acid in the treatment of acanthosis Nigricans: A pilot study","volume":"25","author":"Zayed","year":"2014","journal-title":"J Dermatol Treat"},{"key":"CIT0012-20240429","first-page":"S5","article-title":"Standard guidelines of care for chemical peels","volume":"74","author":"Khunger","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"}],"container-title":["Journal of Cutaneous and Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/JCAS.JCAS_76_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:18:00Z","timestamp":1725088680000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcasonline.com\/efficacy-of-15-trichloroacetic-acid-peel-versus-35-glycolic-acid-peel-in-acanthosis-nigricans-a-randomized-open-label-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jcas.jcas_76_23","relation":{},"ISSN":["0974-2077"],"issn-type":[{"value":"0974-2077","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}