{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:38:35Z","timestamp":1789843115320,"version":"4.0.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Systemic host factors, such as serum 25-hydroxyvitamin D(25[OH]D), may influence periapical healing after root canal treatment (RCT); however, prospective clinical evidence remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate whether baseline serum 25(OH)D levels predict periapical healing and 12-month clinical success following a primary RCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Ninety systemically healthy adults (18\u201350 years old) requiring primary RCT of single-rooted teeth were enrolled. Participants were categorized as Vitamin D\u2013deficient (&lt;20 ng\/mL) or sufficient (\u226520 ng\/mL). The lesion size, periapical index (PAI), pain (Visual Analog Scale), and clinical success were assessed at 6 and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>\n                      This comprised repeated-measures tests, independent group comparisons, receiver operating characteristic (ROC) analysis, and multivariable logistic regression adjusted for baseline lesion size, with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 indicating significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both groups demonstrated significant improvement over time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). At 12 months, the sufficient group demonstrated greater lesion reduction, lower PAI and pain scores, and higher clinical success (93.3% vs. 60.0%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Vitamin D sufficiency independently predicted success (adjusted odds ratio, 6.62;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009). ROC analysis identified 20.4 ng\/mL as the optimal predictive cutoff.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Baseline serum 25(OH)D sufficiency was associated with improved periapical healing and clinical success after primary RCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_141_26","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:01:12Z","timestamp":1777532472000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Baseline serum 25-hydroxyvitamin D levels as a predictor of periapical healing and clinical success after primary root canal treatment: A prospective, observational, and cohort study"],"prefix":"10.4103","volume":"29","author":[{"given":"Manish","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Jawahar Medical Foundation\u2019s Annasaheb Chudaman Patil Memorial Dental College, Dhule, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monali","family":"Nikalje","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Symbiosis Medical College for Women, Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. 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