{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:18:03Z","timestamp":1791566283870,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Persistent\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      infections compromise root canal therapy, with conventional medicaments like calcium hydroxide showing limited efficacy due to bacterial resistance. Novel combinations may improve disinfection outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To compare the antibacterial efficacy of calcium hydroxide with\n                      <jats:italic toggle=\"yes\">Laccifer lacca<\/jats:italic>\n                      , calcium hydroxide alone, and a polyantibiotic paste (Neosporin-H) against\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-eight extracted mandibular premolars were prepared and inoculated with\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      for 21 days. Specimens were divided into four groups: calcium hydroxide, calcium hydroxide +\n                      <jats:italic toggle=\"yes\">Laccifer lacca<\/jats:italic>\n                      (6:4 ratio), Neosporin-H, and untreated controls. After 7 days of medicament placement, dentin scrapings were cultured to assess colony-forming units (CFUs). Statistical analysis was performed using one-way ANOVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CFUs were highest in controls (318.00), reduced with calcium hydroxide (204.57), and further lowered by Neosporin-H (143.00). The calcium hydroxide +\n                      <jats:italic toggle=\"yes\">Laccifer lacca<\/jats:italic>\n                      group showed the greatest reduction (7.71 CFUs;\n                      <jats:italic toggle=\"yes\">F<\/jats:italic>\n                      = 49.64,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Laccifer lacca<\/jats:italic>\n                      significantly enhances calcium hydroxide\u2019s antibacterial activity, offering a promising alternative intracanal medicament for resistant\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_173_26","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:01:38Z","timestamp":1777532498000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Antibacterial efficacy of calcium hydroxide, polyantibiotic paste, and Laccifer lacca combinations: An in vitro study"],"prefix":"10.4103","volume":"29","author":[{"given":"S G","family":"Sreelekshmi","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PMS College of Dental Science and Research, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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