{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:24:42Z","timestamp":1783347882627,"version":"3.54.6"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to compare the effects of different concentrations of nitrofurantoin and triple antibiotic paste (TAP) on the viability and odontoblastic differentiation potential of human dental pulp stem cells (DPSCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>DPSCs were cultured and exposed to serial dilutions of nitrofurantoin and TAP. Cell viability was measured using the MTT assay at 72 h, and alkaline phosphatase (ALP) activity was assessed at 7 days to evaluate differentiation potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      One-way ANOVA with Tukey\u2019s\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      test and independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests; significance at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nitrofurantoin demonstrated significantly superior preservation of DPSC viability compared with TAP across all tested concentrations. ALP activity showed a concentration-dependent increase in both the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nitrofurantoin exhibits superior biocompatibility with DPSCs while maintaining differentiation capacity, making it a promising alternative intracanal medicament for regenerative endodontic procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_192_26","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:13:29Z","timestamp":1783084409000},"page":"717-721","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Direct effect of nitrofurantoin on dental pulp stem cell viability and odontoblastic differentiation potential"],"prefix":"10.4103","volume":"29","author":[{"given":"Santhiya","family":"Ravichandran","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthick","family":"Kumaravadivel","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankar","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bency Joseph","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebeena","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa Natesan","family":"Thangaraj","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"R1-20260706","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.adaj.2016.01.009","article-title":"Regenerative endodontics: A way forward","volume":"147","author":"Diogenes","year":"2016","journal-title":"J Am Dent Assoc"},{"key":"R2-20260706","doi-asserted-by":"crossref","first-page":"530","DOI":"10.4103\/jcd.jcd_535_21","article-title":"Treatment outcome of regenerative endodontic procedures in mature permanent teeth compared to nonsurgical endodontic treatment: A systematic review and meta-analysis","volume":"24","author":"Nangia","year":"2021","journal-title":"J Conserv Dent"},{"key":"R3-20260706","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.joen.2014.01.015","article-title":"Translational science in disinfection for regenerative endodontics","volume":"40","author":"Diogenes","year":"2014","journal-title":"J Endod"},{"key":"R5-20260706","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.joen.2012.06.018","article-title":"Direct effect of intracanal medicaments on survival of stem cells of the apical papilla","volume":"38","author":"Ruparel","year":"2012","journal-title":"J Endod"},{"key":"R6-20260706","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/2128473","article-title":"Assessment of Nitrofurantoin as an Experimental Intracanal Medicament in Endodontics","volume":"2020","author":"Alrahman","year":"2020","journal-title":"Biomed Res Int"},{"key":"R7-20260706","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4103\/JCDE.JCDE_172_24","article-title":"Comparative evaluation of antibacterial efficacy of nitrofurantoin, chitosan, and calcium hydroxide in combination with propylene glycol as an intracanal medicament against endodontic pathogen - 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