{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:35:58Z","timestamp":1786739758709,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>The use of resin-based computer-aided design and computer-aided manufacturing (CAD\/CAM) blocks is increasing in restorative dentistry. However, the potential elution of urethane dimethacrylate (UDMA) into saliva and its associated safety implications remain insufficiently investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To identify and quantify the monomer elution of two different indirect composite blocks before and after thermocycling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>\n                      Two composite CAD-CAM blocks were investigated: a resin-based composite block (RCB, Shofu HC Block) and a polymer-infiltrated ceramic network block (PICN, Vita Enamic). Twenty specimens from each material (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20) were prepared. All specimens (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40) were immersed in artificial saliva at 37\u00b0C for 24 h before thermocycling. Extractions were performed after 24 h of immersion and subsequently after 500 and 10,000 cycles of thermocycling. UDMA monomer elution was analyzed using high performance liquid chromatography (HPLC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>Kruskal\u2013Wallis test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No quantifiable level of UDMA was observed in either RCB or PICN before thermocycling. After 500 cycles of thermocycling, UDMA elution was identified in RCB (0.04 mg\/mL), but remained undetectable in PICN. Following 10,000 cycles of thermocycling, both RCB and PICN showed UDMA release of 0.01 mg\/mL. However, the Kruskal\u2013Wallis test revealed no statistically significant differences among groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The highest UDMA elution occurred in RCB after 500 cycles of thermocycling. Despite differences in polymer structure, thermocycling did not significantly influence UDMA release in either material.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_268_26","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:07:18Z","timestamp":1780074438000},"page":"656-660","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of urethane dimethacrylate monomer elution between indirect composites when subjecting to thermocycling"],"prefix":"10.4103","volume":"29","author":[{"given":"Nur Amalia Mohd","family":"Hanifah","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrifah Nur Athirah A-Idid Syed Mohammed","family":"Idid","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Universiti 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