{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:23Z","timestamp":1786649723949,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Regenerative endodontic procedures initially proposed for dental pulp revascularisation in immature permanent tooth resulted in continued root development, increase thickness of dentinal wall and apical closure. Recently with increased knowledge, REP have been used to successfully treat mature permanent tooth with infected necrotic pulp and apical periodontitis. In present Case series two visit revascularisation procedure was performed by placing I-PRF in the root canals. A 3-mm plug of mineral trioxide aggregate was placed to seal the coronal orifice over semicoagulated blood. The access cavities were restored with composite resin. Followups of the treated cases was done using CBCT as measuring tool to evaluate the successful treatment outcome. There was evident reduction in size of lesion. Clinical signs and symptoms were absent in both cases at followup visits at different time intervals. The purpose of this series was to present the potential of using I-PRF as an alternative and promising treatment approach for management of mature teeth with chronic apical periodontitis.<\/jats:p>","DOI":"10.4103\/jcde.jcde_34_25","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:00:48Z","timestamp":1746493248000},"page":"491-495","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Heal and seal using injectable blood derivative: Case series"],"prefix":"10.4103","volume":"28","author":[{"given":"Shubham","family":"Kingra","sequence":"first","affiliation":[{"name":"Department of Conservative and Endodontics, Adesh Institute of Dental Sciences and Research, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munish","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Conservative and Endodontics, Adesh Institute of Dental Sciences and Research, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Conservative and Endodontics, Adesh Institute of Dental Sciences and Research, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Conservative and Endodontics, Adesh Institute of Dental Sciences and Research, Bathinda, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"R1-20260423","first-page":"333","article-title":"Tissue formation in the root canal following pulp removal","volume":"79","author":"Nygaard-Ostby","year":"1971","journal-title":"Scand J Dent Res"},{"key":"R2-20260423","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.joen.2019.04.005","article-title":"Regenerative endodontic procedures in necrotic mature teeth with periapical radiolucencies: A preliminary randomized clinical study","volume":"45","author":"Arslan","year":"2019","journal-title":"J Endod"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4103\/JCDE.JCDE_362_24","article-title":"Effect of platelet-rich fibrin and concentrated growth factor on the regenerative potential of human-induced pluripotent stem cells: A comparative analysis","volume":"27","author":"Bharti","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"R4-20260423","first-page":"64","article-title":"An update on the protocols and biologic actions of platelet rich fibrin in dentistry","volume":"25","author":"Shah","year":"2017","journal-title":"Eur J Prosthodont Restor Dent"},{"key":"R5-20260423","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4103\/JCDE.JCDE_320_24","article-title":"Comparative evaluation of the osteogenic capacity of second-generation platelet concentrates on dental pulp stem cells \u2013 An ex vivo study","volume":"27","author":"Panda","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"R6-20260423","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.joen.2017.06.012","article-title":"Regenerative endodontics for adult patients","volume":"43","author":"He","year":"2017","journal-title":"J Endod"},{"key":"R7-20260423","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.joen.2013.07.026","article-title":"Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation","volume":"40","author":"Martin","year":"2014","journal-title":"J Endod"},{"key":"R8-20260423","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4103\/JCDE.JCDE_500_24","article-title":"Clinical efficacy of platelet-rich fibrin, injectable platelet-rich fibrin, and advanced platelet-rich fibrin in regenerative endodontics: A case series","volume":"27","author":"Pandey","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"R9-20260423","first-page":"55","article-title":"Une opportunit\u00e9 en paro-implantologie: Le PRF","volume":"42","author":"Choukroun","year":"2001","journal-title":"Implantodontie"},{"key":"R10-20260423","doi-asserted-by":"crossref","first-page":"944.","DOI":"10.3390\/jpm11100944","article-title":"PRP and PRF-subgroups and divisions when used in dentistry","volume":"11","author":"Pietruszka","year":"2021","journal-title":"J Pers Med"},{"key":"R11-20260423","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1365-2591.2009.01633.x","article-title":"One step pulp revascularization treatment of an immature permanent tooth with chronic apical abscess: A case report","volume":"42","author":"Shin","year":"2009","journal-title":"Int Endod J"},{"key":"R12-20260423","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.joen.2008.03.023","article-title":"Biologically based treatment of immature permanent teeth with pulpal necrosis: A case series","volume":"34","author":"Jung","year":"2008","journal-title":"J Endod"},{"key":"R13-20260423","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2591.1983.tb01299.x","article-title":"The effect of canal preparation on periapical disease","volume":"16","author":"Klevant","year":"1983","journal-title":"Int Endod J"},{"key":"R14-20260423","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","article-title":"Injectable platelet rich fibrin (i-PRF): Opportunities in regenerative dentistry?","volume":"21","author":"Miron","year":"2017","journal-title":"Clin Oral Investig"}],"container-title":["Journal of Conservative Dentistry and Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JCDE.JCDE_34_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:38Z","timestamp":1786647458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JCDE.JCDE_34_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jcde.jcde_34_25","relation":{},"ISSN":["2950-4716","2950-4708"],"issn-type":[{"value":"2950-4716","type":"print"},{"value":"2950-4708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-01-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}