{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:50Z","timestamp":1786649750705,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Background:<\/jats:title>\n Dental caries induces a chronic inflammatory response leading to systemic oxidative stress through excessive reactive oxygen species generation. Restorative treatment may modulate this imbalance, with salivary malondialdehyde (MDA) serving as a reliable biomarker of oxidative stress reduction.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The aim is to evaluate the effect of Cention N and nano composite restorative materials on caries-induced systemic oxidative stress, assessed through reactive oxygen species (ROS) modulation using salivary MDA as a biomarker.<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods:<\/jats:title>\n Sixty patients with dental caries in a single tooth not involving the pulp were selected for the study. Informed consent and institutional ethical approval were obtained for the same. The individuals were divided into two groups based on the type of restorative material planned for them, i.e., Cention N and Nano composite. Five milliliter saliva samples were collected before as well as 24 h, 7 days, and 14 days postrestoration. The salivary oxidative stress (OS) was assessed at all-time points using salivary MDA as a biomarker, and the findings were statistically analyzed.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n \n Data were analyzed using SPSS 30.0 version software using Kolmogorov\u2013Smirnov test, followed by Mann\u2013Whitney\n U<\/jats:italic>\n test and the Friedman test.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n At all three postrestoration time points, Cention N produced a more pronounced reduction in oxidative stress marker levels when compared to the nanohybrid composite, indicating superior antioxidative potential.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n It may, therefore, be concluded that Cention N restorative material results in rapid and superior reduction of caries-induced inflammatory stress in the body as compared to nano-composite restorative material.<\/jats:p>\n 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