{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:07Z","timestamp":1787775787018,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"\n Aim:<\/jats:title>\n \n This study aimed to evaluate the effectiveness of combining\n Channa striata<\/jats:italic>\n extract with calcium hydroxide (Ca(OH)2) in reducing lymphocyte counts and interleukin (IL)-1\u03b2 levels in inflamed pulp teeth.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n A laboratory experimental setup with a posttest control group (CG) design was employed. Thirty-two rat incisor teeth were divided into four groups: a positive CG (100% Ca(OH)2), treatment 1 (25%\n C. striata<\/jats:italic>\n extract + 75% Ca(OH)2), treatment 2 (50%\n C. striata<\/jats:italic>\n extract + 50% Ca(OH)2), and treatment 3 (75%\n C. striata<\/jats:italic>\n extract + 25% Ca(OH)2). These test materials were applied to Class 1 cavities extending to the pulp roof, with samples collected on days 1, 3, 5, and 7. Data were analyzed using analysis of variance and\n post hoc<\/jats:italic>\n least significant difference tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In all the groups, the highest levels of lymphocytes and IL-1\u03b2 were observed on day 3, followed by a decline on days 5 and 7. The combination of\n C. striata<\/jats:italic>\n extract with Ca(OH)2 significantly reduced inflammatory markers, particularly lymphocyte and IL-1\u03b2 levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The extract of\n C. striata<\/jats:italic>\n holds significant potential as an innovative therapeutic approach for managing inflamed dental pulp.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcde.jcde_407_24","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T15:27:27Z","timestamp":1725722847000},"page":"942-948","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Potential application of a combined extract of Channa striata and calcium hydroxide for inhibiting lymphocytes and interleukin-1\u03b2 cells in the asymptomatic irreversible pulpitis of Wistar rats (Rattus norvegicus)"],"prefix":"10.4103","volume":"27","author":[{"given":"Juni Jekti","family":"Nugroho","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia"},{"name":"Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risnawati","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aries Chandra","family":"Trilaksana","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia"},{"name":"Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahyuni Suci","family":"Dwiandhany","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia"},{"name":"Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/jcd.jcd_241_23","article-title":"A paradigm shift from calcium hydroxide to bioceramics in direct pulp capping: A narrative review","volume":"27","author":"Al-Saudi","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"R5-20260427","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/j.0022-0337.2003.67.6.tb03668.x","article-title":"Vitality of the dentin-pulp 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