{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:23:48Z","timestamp":1793463828326,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"Abstract<\/jats:title>\n \n Context:<\/jats:title>\n The choice of material for indirect pulp capping (IPC) may affect long-term pulp vitality, particularly with newer bioactive cements.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The aim of this study was to compare the clinical and radiographic efficacy of TheraCal LC, Binar LC, calcium-enriched mixture (CEM) cement, and calcium hydroxide as IPC agents in mature permanent teeth with deep carious lesions.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In this prospective randomized trial, 52 patients with deep caries and reversible pulpitis were divided into four groups (\n n<\/jats:italic>\n = 13). Standardized IPC procedures and follow-ups at 21 days, 3 months, and 6 months included clinical and radiographic evaluations.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n ANOVA and Tukey\u2019s post hoc tests analyzed pain (Visual Analog Scale scores); Chi-square tests compared categorical variables.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All materials maintained pulp vitality without significant differences (\n P<\/jats:italic>\n > 0.05). CEM cement achieved 100% success with no radiographic abnormalities. TheraCal LC and Binar LC performed well, while calcium hydroxide showed slightly more failures and a higher incidence of PDL widening.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n All tested materials were effective IPC agents; however, bioactive materials (CEM cement and TheraCal LC) demonstrated superior clinical outcomes and sealing ability versus traditional calcium hydroxide.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcde.jcde_507_25","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:00:25Z","timestamp":1759593625000},"page":"1013-1018","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Comparative evaluation of four different calcium-based medicaments as an indirect pulp capping agent: An in vivo study"],"prefix":"10.4103","volume":"28","author":[{"given":"Ray Anuja","family":"Awadhesh","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kararia","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachit","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotirmoyee","family":"Bhanja","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, NIMS Dental College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4103\/JCDE.JCDE_63_24","article-title":"Treatment outcome of coronal pulpotomy and indirect pulp capping in mature permanent molars with symptoms of moderate pulpitis:A randomized clinical trial","volume":"27","author":"Gabriel","year":"2024","journal-title":"J Conserv Dent 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experimental capping with mineral trioxide aggregate","volume":"54","author":"Nair","year":"2021","journal-title":"Int Endod J"},{"key":"R13-20251006","first-page":"451","article-title":"Randomized trial comparing platelet-rich fibrin and calcium hydroxide as pulp capping biomaterials","volume":"24","author":"Verma","year":"2021","journal-title":"J Conserv Dent"},{"key":"R14-20251006","first-page":"S33","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements:An updated overview \u2013Part II:Other clinical applications and complications","volume":"46","author":"Parirokh","year":"2020","journal-title":"J Endod"},{"key":"R15-20251006","first-page":"276","article-title":"Bioactivity and sealing ability of newer calcium silicate-based materials versus calcium hydroxide in direct pulp capping:An in vivo study","volume":"23","author":"Patel","year":"2020","journal-title":"J Conserv Dent"},{"key":"R16-20251006","first-page":"298","article-title":"Investigation of the hydration and bioactivity of radiopacified tricalcium silicate cement, Biodentine and MTA angelus","volume":"37","author":"Camilleri","year":"2021","journal-title":"Dent Mater"},{"key":"R17-20251006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.joen.2020.06.025","article-title":"Full pulpotomy with Biodentine in symptomatic young permanent teeth with carious exposure","volume":"46","author":"Taha","year":"2020","journal-title":"J Endod"},{"key":"R18-20251006","first-page":"542","article-title":"Comparison of CaOH with MTA for direct pulp capping:A PBRN randomized clinical trial","volume":"152","author":"Hilton","year":"2021","journal-title":"J Am Dent Assoc"},{"issue":"Suppl 1","key":"R19-20251006","first-page":"46","article-title":"European Society of Endodontology position statement:Management of deep caries and the exposed pulp","volume":"55","author":"Duncan","year":"2022","journal-title":"Int Endod 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