{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:46Z","timestamp":1787841106076,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Aim:<\/jats:title>\n To evaluate the anesthetic efficacy of inferior alveolar nerve block (IANB) with 4% articaine versus laser-assisted articaine supplementation for profound pulpal anesthesia during single-visit root canal treatment (RCT) of the mandibular molars with symptomatic irreversible pulpitis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This prospective double-blinded randomized controlled trial enrolled 64 patients (aged 18\u201355 years) with clinically\/radiographically confirmed symptomatic irreversible pulpitis in the mandibular molars. After standard IANB (1.8 mL 4% articaine 1:100,000 epinephrine), patients with persistent moderate\u2013severe pain (Visual Analog Scale [VAS]: \u22654) were randomized into two groups (\n n<\/jats:italic>\n = 32 each). The laser group received a 980-nm diode laser (1.5 W, continuous wave, noncontact, 60\u2013180 s\/canal, 10\u201330 J\/cm\u00b2) at the apical third. The control group received supplementary intraligamentary (0.2\u20130.4 mL\/canal) and buccal infiltration with articaine. Primary outcomes were pre operative and intraoperative pain (VAS:0-10). Secondary outcomes were supplemental anesthesia needs and treatment success. Wilcoxon signed-rank test (intragroup) and Mann\u2013Whitney\n U<\/jats:italic>\n -test (intergroup) tests (\n P<\/jats:italic>\n < 0.05, SPSS v. 25) were used for statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age was 33.97 \u00b1 12.07 years in the diode laser group and 38.66 \u00b1 12.22 years in the articaine group, with comparable gender distribution between groups. Preoperative pain scores were similar (median = 8;\n P<\/jats:italic>\n = 0.320). Intraoperatively, the laser group demonstrated significantly lower pain scores (median = 0, IQR 0\u20131) compared with the articaine group (median = 3, IQR 2\u20134;\n P<\/jats:italic>\n < 0.01). Both groups showed a significant reduction in pain from preoperative to intraoperative periods (\n P<\/jats:italic>\n < 0.01). All cases completed single-visit without adverse effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The 980-nm diode laser significantly enhances IANB over articaine infiltration, providing superior pain control for single-visit RCT in irreversible pulpitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcde.jcde_61_26","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:00:17Z","timestamp":1774850417000},"page":"430-434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effect of laser-assisted articaine local anesthesia in single visit root canal treatment for mandibular molar with symptomatic irreversible pulpitis - A randomized clinical trial"],"prefix":"10.4103","volume":"29","author":[{"given":"S. Jency","family":"Abarna","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanavel","family":"Chakravarthy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Vijaya","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravindhan","family":"Venkatapathi","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Soundarya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Hari","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"R1-20260416","doi-asserted-by":"crossref","first-page":"e806","DOI":"10.61919\/yak6gh20","article-title":"Effect of low-level laser therapy (LLLT) on pain at injection site of local anesthetic agent","volume":"3","author":"Ayaz","year":"2025","journal-title":"J Health Wellness Community Res"},{"key":"R2-20260416","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: A clinical study","volume":"19","author":"Cohen","year":"1993","journal-title":"J 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