{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:49:42Z","timestamp":1787071782040,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Context:<\/jats:title>\n Despite its outstanding properties, extended use of calcium hydroxide (CH) causes a reduction in dentin strength, increasing the tooth\u2019s vulnerability to fracture.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n This\n in vitro<\/jats:italic>\n study aimed to compare and assess the fracture resistance (FR) of root dentin when CH with and without the addition of niobium pentoxide (NP) was used as an intracanal medicament (ICM) and its solubility over a period of time.\n <\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n \n Eighty teeth with single roots were decoronated, instrumented with Protaper till F3. The teeth were randomly divided into baseline (\n n<\/jats:italic>\n = 5), without medicament, CH, and CH + NP (\n n<\/jats:italic>\n = 25 each) and subjected to FR testing at different time periods. For the solubility rate, the American Dental Association specification #8 was adopted and tested at various time intervals.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n \n One-way ANOVA along with Tukey\u2019s honestly significant difference\n post hoc<\/jats:italic>\n Test.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n CH + NP exhibited statistically significantly higher FR than CH at 1 month. The increase was statistically insignificant for the remaining intervals. CH + NP (94.4%) and CH (87.5%) showed the highest percentage of solubility at 1-month interval.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n CH + NP can be effectively used as an ICM with easy retrievability.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcde.jcde_650_25","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T17:00:43Z","timestamp":1765299643000},"page":"1211-1214","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of niobium pentoxide incorporated calcium hydroxide as an intracanal medicament on fracture resistance of root canal dentin"],"prefix":"10.4103","volume":"28","author":[{"given":"Nadimpalli Teja","family":"Varma","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SRM Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatappan","family":"Sujatha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SRM Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittappa","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SRM Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekar","family":"Mahalaxmi","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SRM Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"54","DOI":"10.14744\/eej.2020.42714","article-title":"Endodontic periapical lesion: An overview on the etiology, diagnosis and current treatment modalities","volume":"5","author":"Karamifar","year":"2020","journal-title":"Eur Endod J"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-024-00280-5","article-title":"Expert consensus on irrigation and intracanal medication in root canal therapy","volume":"16","author":"Zou","year":"2024","journal-title":"Int J Oral Sci"},{"issue":"Suppl 3","key":"R3-20260420","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/iej.13731","article-title":"Present status and future directions of intracanal medicaments","volume":"55","author":"Ordinola-Zapata","year":"2022","journal-title":"Int Endod J"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/01.don.0000194542.02521.af","article-title":"Fracture resistance of human root dentin exposed to intracanal calcium hydroxide","volume":"31","author":"Doyon","year":"2005","journal-title":"J Endod"},{"key":"R5-20260420","first-page":"74","article-title":"Tantalum, niobium and titanium coatings for biocompatibility improvement of dental implants","volume":"4","author":"Fathi","year":"2007","journal-title":"Dent Res J"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jdent.2012.04.022","article-title":"Niobium pentoxide as a novel filler for dental adhesive resin","volume":"41","author":"Leitune","year":"2013","journal-title":"J Dent"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/aej.12611","article-title":"Calcium hydroxide and niobium pentoxide treatment effects before MTA placement","volume":"49","author":"Sankeerthana","year":"2023","journal-title":"Aust Endod J"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0972-0707.58338","article-title":"Comparison of fracture resistance of endodontically treated teeth using different coronal restorative materials: An in vitro study","volume":"12","author":"Monga","year":"2009","journal-title":"J Conserv Dent"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0099-2399(06)81262-8","article-title":"Effects of moisture content and endodontic treatment on some mechanical properties of human dentin","volume":"18","author":"Huang","year":"1992","journal-title":"J Endod"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"73","DOI":"10.14744\/eej.2023.19971","article-title":"Comparative evaluation of the effect of different chelating agents on mineral content and erosion of radicular dentine: A FESEM-EDS analysis","volume":"9","author":"Kadulkar","year":"2024","journal-title":"Eur Endod J"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5395\/rde.2014.39.4.241","article-title":"Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: A literature review \u2013 Part I. 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