{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:37Z","timestamp":1786728517401,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Overview:<\/jats:title>\n                    <jats:p>\n                      Residual pathogens lead to treatment failure. Microbes like\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Actinomyces israelii<\/jats:italic>\n                      are often isolated after failed root canal therapy. Therefore, the antimicrobial efficacy of sealers is critical for treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To evaluate the antimicrobial efficacy of endodontic sealers against\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>The agar diffusion test was used to evaluate the antibacterial efficacy of four sealers: MTA Fillapex, Bio-C-Sealer, Sealapex, and Seal-Pex. Each microorganism\u2019s bacterial suspension was added to agar plates separately. The sterile discs were then placed on the plates; later, a freshly mixed sealer was coated on the sterile discs. After 24 h of incubation, inhibition zones were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Kruskal\u2013Wallis test was used to analyze the data, and the Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      -test was used for\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      pairwise comparison. The results demonstrated that Seal-Pex has potent antibacterial activity against E. faecalis (P &lt; 0.05). Against C. albicans, both MTA Fillapex and Seal-Pex were effective, with MTA Fillapex showing a statistically significant difference compared to Bio-C Sealer and Sealapex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Seal-Pex, an epoxy resin-based sealer, exhibited a significant antimicrobial efficacy against\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      . Conversely, MTA Fillapex demonstrated notable antifungal activity against\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      , surpassing other tested sealers. These findings highlight the differential antimicrobial and antifungal properties of the sealers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_841_24","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T01:00:34Z","timestamp":1740963634000},"page":"264-268","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the antimicrobial effectiveness of endodontic sealers against oral pathogens associated with failed root canal treatments"],"prefix":"10.4103","volume":"28","author":[{"given":"Ajay","family":"Chhabra","sequence":"first","affiliation":[{"name":"Department of Dentistry, AIIMS, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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