{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:44:41Z","timestamp":1790959481409,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      The present study aimed to evaluate and compare the effects of three intracanal medicaments \u2013 calcium hydroxide (Ca(OH)\n                      <jats:sub>2<\/jats:sub>\n                      ), modified triple antibiotic paste (MTAP), and Bio-C Temp \u2013 on the microhardness of root dentin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty extracted mandibular premolars with single canals were decoronated and standardized to 14 mm length. Following biomechanical preparation using ProTaper rotary instruments, the specimens were randomly allocated into four groups: Ca(OH)\n                      <jats:sub>2<\/jats:sub>\n                      , MTAP, Bio-C Temp, and a control group without medicament. The medicaments were placed using a lentulospiral and the canals sealed. All samples were incubated at 37\u00b0C in 100% humidity for 14 days. Mid-root dentin discs of 2 mm thickness were obtained and microhardness was assessed using a Vickers hardness tester under a 200 g load for 15 s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>\n                      Data were analyzed using the Kruskal\u2013Wallis test, followed by one-way ANOVA and Tukey\u2019s\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      pairwise comparisons. The significance level was set at 5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      MTAP produced the greatest reduction in dentin microhardness, followed by Ca(OH)\n                      <jats:sub>2<\/jats:sub>\n                      , while Bio-C Temp showed the least reduction. The control group exhibited the highest values. Differences among groups were statistically significant, except between Bio-C Temp and the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Bio-C Temp preserved dentin microhardness more effectively than Ca(OH)\n                      <jats:sub>2<\/jats:sub>\n                      and MTAP, indicating its potential as a favorable intracanal medicament with minimal adverse structural effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcde.jcde_955_25","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:00:25Z","timestamp":1768068025000},"page":"114-118","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Comparative evaluation of the effect of intracanal medicaments calcium hydroxide, modified triple antibiotic paste, and Bio-C Temp on root dentin microhardness: An in vitro study"],"prefix":"10.4103","volume":"29","author":[{"given":"Tanmayi D.","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, ACPM Dental College and Hospital, Dhule, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranthikumar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, ACPM Dental College and Hospital, Dhule, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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