{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:19Z","timestamp":1787775739973,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background:<\/jats:title>\n \n Various formulations of medicaments have been used to eradicate\n Enterococcus faecalis<\/jats:italic>\n and\n Candida albicans<\/jats:italic>\n in secondary endodontic infection. Sodium dichloroisocyanurate (NaDCC) has proven potency to act against\n E. faecalis<\/jats:italic>\n . However, research against both\n E. faecalis<\/jats:italic>\n and\n C. albicans<\/jats:italic>\n as an intracanal medicament at different time intervals is yet to be evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n The aim of this study was to compare and evaluate the antimicrobial efficacy of NaDCC against\n E. faecalis<\/jats:italic>\n and\n C. albicans<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Ninety-six mandibular single-rooted premolars were randomly divided into two groups for inoculation of\n E. faecalis<\/jats:italic>\n and\n C. albicans<\/jats:italic>\n . They were then divided into four groups: Group 1 was treated with ketoconazole, Group 2 with NaDCC, Group 3 with calcium hydroxide (CH), and Group 4 with 2% chlorhexidine. These medicaments were placed inside the root canal using lentulo spirals, sealed, and incubated under aerobic conditions. At the end of 3 and 7 days, the antimicrobial efficacy was assessed by calculating the colony forming unit\/mL (CFU\/ml) against\n E. faecalis<\/jats:italic>\n and\n C. albicans<\/jats:italic>\n using a digital colony counter. Analysis of variance and paired\n t<\/jats:italic>\n -test were used for statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n NaDCC exhibited superior results against E. faecalis and C. albicans after 3 and 7 days compared to chlorhexidine and CH.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n NaDCC can be considered a potential alternative to calcium hydroxide and chlorhexidine as an intracanal medicament for effective root canal disinfection and in secondary endodontic infection.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jcde.jcde_99_25","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T01:00:47Z","timestamp":1746493247000},"page":"444-448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of antimicrobial efficacy of sodium dichloroisocyanurate as an intracanal medicament against Enterococcus faecalis and Candida albicans"],"prefix":"10.4103","volume":"28","author":[{"given":"Sangita","family":"Ilango","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sri Venkateswara Dental College and Hospital, Affiliated to TNMGRMU, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadasiva","family":"Kadandale","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Chettinad Dental College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanya","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of 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