{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:29:50Z","timestamp":1786728590357,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clear renal cell carcinoma (RCC) represents the most prevalent type of kidney cancer, with a tendency for venous migration and extension into the inferior vena cava (IVC) in 4%\u201310% of the cases. Herein, we present a case report of a patient with acute coronary syndrome and an incidental echocardiographic finding of a thrombus in the IVC, which contributed to the diagnosis of the RCC. A 67-year-old male patient was transferred to our clinic with high troponin levels and electrocardiogram changes suggestive of myocardial ischemia. Coronary angiography revealed occlusion of the right coronary artery and left anterior descending with normal flow through the graft. During the two-dimensional transthoracic echocardiographic examination, in the subcostal view, a thrombotic formation in the IVC was observed. A computed tomography of the abdomen showed an oval mass on the upper pole of the left kidney. The patient underwent an open radical nephrectomy. Pathological examination confirmed the diagnosis of clear RCC. The patient consulted the oncology department, where no specific oncological therapy was indicated. After a 2-year follow-up, ultrasound of the abdomen was normal, without relapse or metastatic dissemination of the RCC. Detailed echocardiographic assessment can reveal pathological changes even in the surrounding structures, which helps in the timely diagnosis and initiation of treatment in the early stages of the disease.<\/jats:p>","DOI":"10.4103\/jcecho.jcecho_101_24","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:00:16Z","timestamp":1759294816000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Multidisciplinary Role of Echocardiography: From the Thrombus in Inferior Vena Cava to the Diagnosis of Renal Cell Carcinoma"],"prefix":"10.4103","volume":"35","author":[{"given":"Elif","family":"Vraynko","sequence":"first","affiliation":[{"name":"University Clinic of Cardiology, Faculty of Medicine, University of \u201cSs. Cyril and Methodius\u201d Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Andova","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology, Faculty of Medicine, University of \u201cSs. Cyril and Methodius\u201d Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gjulsen","family":"Selim","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology, Faculty of Medicine, University of \u201cSs. Cyril and Methodius\u201d Skopje, Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Georgievska-Ismail","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology, Faculty of Medicine, University of \u201cSs. Cyril and Methodius\u201d Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"R1-20251010","first-page":"e32978","article-title":"Arare case of renal cell carcinoma with inferior vena cava invasion: A life-threatening complication","volume":"14","author":"Nduji","year":"2022","journal-title":"Cureus"},{"key":"R2-20251010","first-page":"247","article-title":"Renal cell carcinoma with IVC thrombi;current concepts and future perspectives","volume":"2","author":"Nouh","year":"2008","journal-title":"Clin Med Oncol"},{"key":"R3-20251010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/8756479314549194","article-title":"The incidental finding of hepatocellular carcinoma by echocardiography","volume":"30","author":"Alsandok","year":"2014","journal-title":"J Diagnsotic Med Sonography"},{"key":"R4-20251010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.echo.2014.01.026","article-title":"Extracardiac findings on routine echocardiographic examinations","volume":"27","author":"Alkhouli","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"R5-20251010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.14740\/wjon1279","article-title":"Epidemiology of renal cell carcinoma","volume":"11","author":"Padala","year":"2020","journal-title":"World J Oncol"},{"key":"R6-20251010","first-page":"394","article-title":"Global cancer statistics. 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R7-20251010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ucl.2008.07.005","article-title":"Epidemiology, clinical staging, and presentation of renal cell carcinoma","volume":"35","author":"Decastro","year":"2008","journal-title":"Urol Clin North Am"},{"key":"R8-20251010","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/1756287215576443","article-title":"Management of inferior vena cava tumor thrombus in locally advanced renal cell carcinoma","volume":"7","author":"Psutka","year":"2015","journal-title":"Ther Adv Urol"},{"key":"R9-20251010","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0022-5347(17)32288-7","article-title":"Preoperative computerized tomography detection of extensive invasion of the inferior vena cava by renal cell carcinoma: Possible indication for resection with partial cardiopulmonary bypass and patch grafting","volume":"152","author":"Gohji","year":"1994","journal-title":"J Urol"},{"key":"R10-20251010","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/bju.13005","article-title":"Clinical and radiographic predictors of the need for inferior vena cava resection during nephrectomy for patients with renal cell carcinoma and caval tumour thrombus","volume":"116","author":"Psutka","year":"2015","journal-title":"BJU Int"},{"key":"R12-20251010","first-page":"1","article-title":"Impact of geographic regions on overall survival in patients with metastatic renal cell carcinoma: Results from an international clinical trials database","volume":"4","author":"Fay","year":"2018","journal-title":"J Glob Oncol"},{"key":"R13-20251010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/sj.neo.7900263","article-title":"The hypercoagulable state of malignancy: Pathogenesis and current debate","volume":"4","author":"Caine","year":"2002","journal-title":"Neoplasia"}],"container-title":["Journal of Cardiovascular Echography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_101_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:28:59Z","timestamp":1786724939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_101_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jcecho.jcecho_101_24","relation":{},"ISSN":["2211-4122","2347-193X"],"issn-type":[{"value":"2211-4122","type":"print"},{"value":"2347-193X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-12-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}