{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:45:50Z","timestamp":1786736750836,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Echography"],"published-print":{"date-parts":[[2020]]},"DOI":"10.4103\/jcecho.jcecho_13_20","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T06:09:24Z","timestamp":1604556564000},"page":"154","source":"Crossref","is-referenced-by-count":10,"title":["Severe aortic valve stenosis: Symptoms, biochemical markers, and global longitudinal strain"],"prefix":"10.4103","volume":"30","author":[{"given":"Paolo","family":"Zappulla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bottaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Deste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fam\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Agnello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Trovato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Indelicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Sgroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"InesP","family":"Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2211-4122.300082-1","first-page":"162","volume-title":"Epidemiology of valvular heart disease in the adult","author":"Iung","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"key-10.4103\/2211-4122.300082-2","first-page":"962","volume-title":"Epidemiology of acquired valvular heart disease","author":"Iung","year":"2014","journal-title":"Can J Cardiol"},{"key":"key-10.4103\/2211-4122.300082-3","first-page":"1220","volume-title":"Prevalence of aortic valve abnormalities in the elderly: An echocardiographic study of a random population sample","author":"Lindroos","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"key-10.4103\/2211-4122.300082-4","unstructured":"Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Fleisher LA, et al. 2017 AHA\/ACC Focused Update of the 2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation; 15 March, 2017."},{"key":"key-10.4103\/2211-4122.300082-5","first-page":"803","volume-title":"Impact of preoperative symptoms on postoperative survival in severe aortic stenosis: implications for the timing of surgery","author":"Pi\u00e9rard","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"key-10.4103\/2211-4122.300082-6","first-page":"19","volume-title":"Left ventricular systolic function in aortic stenosis","author":"Krayenbuehl","year":"1988","journal-title":"Eur Heart J"},{"key":"key-10.4103\/2211-4122.300082-7","first-page":"195","volume-title":"Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy","author":"Aurigemma","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"key-10.4103\/2211-4122.300082-8","first-page":"215","volume-title":"Functional importance of the long axis dynamics of the human left ventricle","author":"Jones","year":"1990","journal-title":"Br Heart J"},{"key":"key-10.4103\/2211-4122.300082-9","first-page":"613","volume-title":"Global strain in severe aortic valve stenosis: Relation to clinical outcome after aortic valve replacement","author":"Dahl","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"key-10.4103\/2211-4122.300082-10","first-page":"1194","volume-title":"Natriuretic peptides in heart valve disease","author":"Ray","year":"2006","journal-title":"Heart"},{"key":"key-10.4103\/2211-4122.300082-11","first-page":"1884","volume-title":"Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis","author":"Gerber","year":"2003","journal-title":"Circulation"},{"key":"key-10.4103\/2211-4122.300082-12","first-page":"2302","volume-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","author":"Bergler-Klein","year":"2004","journal-title":"Circulation"},{"key":"key-10.4103\/2211-4122.300082-13","first-page":"984","volume-title":"Usefulness of plasma B-type natriuretic peptide in the assessment of disease severity and prediction of outcome after aortic valve replacement in patients with severe aortic stenosis","author":"Iwahashi","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"key-10.4103\/2211-4122.300082-14","first-page":"331","volume-title":"Natriuretic peptides and long-term mortality in patients with severe aortic stenosis","author":"Katz","year":"2012","journal-title":"J Heart Valve Dis"},{"key":"key-10.4103\/2211-4122.300082-15","first-page":"2848","volume-title":"B-type natriuretic peptide in low-flow, low-gradient aortic stenosis: Relationship to hemodynamics and clinical outcome: Results from the Multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) study","author":"Bergler-Klein","year":"2007","journal-title":"Circulation"},{"key":"key-10.4103\/2211-4122.300082-16","first-page":"371","volume-title":"Determinants and prognostic value of B-type natriuretic peptide in patients with aortic valve stenosis","author":"Nguyen","year":"2017","journal-title":"Int J Cardiol"},{"key":"key-10.4103\/2211-4122.300082-17","doi-asserted-by":"crossref","unstructured":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of, Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2016;17:412.","DOI":"10.1093\/ehjci\/jew041"},{"key":"key-10.4103\/2211-4122.300082-18","first-page":"1","volume-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","author":"Baumgartner","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"key-10.4103\/2211-4122.300082-19","first-page":"3037","volume-title":"Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement","author":"Delgado","year":"2009","journal-title":"Eur Heart J"},{"key":"key-10.4103\/2211-4122.300082-20","first-page":"938","volume-title":"Incremental prognostic value of left ventricular global longitudinal strain in patients with aortic stenosis and preserved ejection fraction","author":"Kusunose","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"key-10.4103\/2211-4122.300082-21","first-page":"727","volume-title":"Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography","author":"Klaeboe","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"key-10.4103\/2211-4122.300082-22","first-page":"248","volume-title":"Left ventricular fibre architecture in man","author":"Greenbaum","year":"1981","journal-title":"Br Heart J"},{"key":"key-10.4103\/2211-4122.300082-23","first-page":"265","volume-title":"Structural analysis of arteriolar and myocardial remodeling in the subendocardial region of patients with hypertensive heart diseases and hypertrophic cardiomyopathy","author":"Mundhenke","year":"1997","journal-title":"Virchows Arch Int J Pathol"},{"key":"key-10.4103\/2211-4122.300082-24","first-page":"443","volume-title":"Longitudinal systolic shortening of the left ventricle: an echocardiographic study in subjects with and without preserved global function","author":"Alam","year":"1992","journal-title":"Clin Physiol"},{"key":"key-10.4103\/2211-4122.300082-25","first-page":"252","volume-title":"Longitudinal systolic strain and strain rate analysis in adult and elderly patients","author":"Santillo","year":"2009","journal-title":"G GERONTOL"},{"key":"key-10.4103\/2211-4122.300082-26","first-page":"2016","volume-title":"B-type natriuretic peptide clinical activation in aortic stenosis: impact on long-term survival","author":"Clavel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"key-10.4103\/2211-4122.300082-27","first-page":"611","volume-title":"Predictors of outcome in severe, asymptomatic aortic stenosis","author":"Rosenhek","year":"2000","journal-title":"N Engl J Med"},{"key":"key-10.4103\/2211-4122.300082-28","first-page":"1445","volume-title":"Usefulness of an elevated B-type natriuretic peptide in predicting survival in patients with aortic stenosis treated without surgery","author":"Nessmith","year":"2005","journal-title":"Am J Cardiol"},{"key":"key-10.4103\/2211-4122.300082-29","doi-asserted-by":"crossref","unstructured":"Goodman A, Kusunose K, Popovic ZB, Parikh R, Barr T, Sabik JF, et al. Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Strain in Patients With Significant Aortic Stenosis. J Am Heart Assoc 2016;5.","DOI":"10.1161\/JAHA.115.002561"},{"key":"key-10.4103\/2211-4122.300082-30","first-page":"316","volume-title":"The role of cardiac biochemical markers in aortic stenosis","author":"Chin","year":"2016","journal-title":"Biomarkers"},{"key":"key-10.4103\/2211-4122.300082-31","first-page":"1909","volume-title":"Value of ejection fraction\/velocity ratio in the prognostic stratification of patients with asymptomatic aortic valve stenosis","author":"Antonini-Canterin","year":"2018","journal-title":"Echocardiography"},{"key":"key-10.4103\/2211-4122.300082-32","doi-asserted-by":"crossref","unstructured":"Di Nora C, Cervesato E, Cosei I, Ravasel A, Popescu BA, Zito C, et al. New classification of geometric ventricular patterns in severe aortic stenosis: Could it be clinically useful? Echocardiography 2018;35:1077-84","DOI":"10.1111\/echo.13892"},{"key":"key-10.4103\/2211-4122.300082-33","doi-asserted-by":"crossref","unstructured":"Mazzone C, Cioffi G, Di Nora C, Barbati G, Guidetti F, Faggiano P, et al. Prognostic role of cardiac calcifications in primary prevention: A powerful marker of adverse outcome highly dependent on underlying cardiac rhythm. Int J Cardiol 2018;258:262-8","DOI":"10.1016\/j.ijcard.2018.01.101"}],"container-title":["Journal of Cardiovascular Echography"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:45:49Z","timestamp":1786733149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_13_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"alternative-id":["300082"],"URL":"https:\/\/doi.org\/10.4103\/jcecho.jcecho_13_20","relation":{},"ISSN":["2211-4122"],"issn-type":[{"value":"2211-4122","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}