{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:21Z","timestamp":1788182481976,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To establish the reference values for the angle between the atrioventricular (AV) valve insertion levels in fetal hearts using three-dimensional ultrasound with Spatio-temporal Image Correlation (STIC) rendering and to validate these values in fetuses with confirmed congenital heart disease (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study was conducted using 59 STIC volumes from structurally normal fetuses between 20 and 33 + 6 weeks of gestation. The AV valve insertion angle was measured in the rendering mode of four-chamber view. A polynomial regression model was used to generate a reference curve and percentile table. A validation cohort of 26 fetuses with CHD was analyzed, and angle distributions were compared with the normative percentiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The insertion angle remained stable throughout gestation. Reference percentiles (5\n                      <jats:sup>th<\/jats:sup>\n                      , 10\n                      <jats:sup>th<\/jats:sup>\n                      , 50\n                      <jats:sup>th<\/jats:sup>\n                      , 90\n                      <jats:sup>th<\/jats:sup>\n                      , and 95\n                      <jats:sup>th<\/jats:sup>\n                      ) were established by gestational week. Among fetuses with CHD, 46.2% had angles below the 5\n                      <jats:sup>th<\/jats:sup>\n                      percentile and 57.7% above the 95\n                      <jats:sup>th<\/jats:sup>\n                      percentile, with only 7.7% within the normal range. Specific CHD such as tetralogy of Fallot, transposition of the great arteries, and truncus arteriosus showed consistent deviations from normal values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The AV valve insertion angle was a stable parameter throughout gestation and demonstrates significant deviation in fetuses with CHD. This measurement may serve as a useful screening tool for early prenatal identification of certain structural CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcecho.jcecho_14_26","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:04:08Z","timestamp":1778144648000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Three-dimensional Evaluation of Atrioventricular Valve Geometry in the Fetal Heart: Establishing Reference Standards and Clinical Validation"],"prefix":"10.4103","volume":"36","author":[{"given":"Tassyele Pamplona","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine - Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Yanno","family":"Callado","sequence":"additional","affiliation":[{"name":"Discipline of Woman Health, Albert Einstein Israelite College of Health Sciences, Albert Einstein Israelite Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Jeanne","family":"Bravo-Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Araujo","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine - Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo, 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