{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:20Z","timestamp":1788182480425,"version":"build-2803163510"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Eosinophilic myocarditis (EM) is a rare entity, characterized by a heterogeneous clinical presentation, ranging from acute heart failure to acute coronary syndrome, and associated with severe complications. Herein, we describe the case of a 78-year-old woman who presented to the ED with chest pain, elevated cardiac biomarkers, T-wave inversion on the electrocardiogram, left ventricular systolic dysfunction, and intraventricular thrombus (confirmed by contrast echo). Coronary angiography revealed the absence of obstructive coronary artery disease. Cardiac magnetic resonance (CMR) demonstrated the findings consistent with myocarditis. Due to concomitant hypereosinophilia, an endomyocardial biopsy (EB) was performed, revealing eosinophilic infiltrates. A diagnosis of EM was therefore established, and treatment with corticosteroids and anti\u2013interleukin-5 monoclonal antibodies was initiated. This case report highlights the importance of early diagnosis of EM, a potentially elusive condition with misleading clinical features. In cases of suspected EM, CMR and, when feasible, EB are crucial to establish the diagnosis and guide appropriate therapy.<\/jats:p>","DOI":"10.4103\/jcecho.jcecho_35_26","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:03:19Z","timestamp":1778144599000},"page":"476-480","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking Eosinophilic Myocarditis: Importance of Multimodality Imaging and Histological Confirmation in a Challenging Case"],"prefix":"10.4103","volume":"36","author":[{"given":"Simone","family":"Luciani","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, Cardiology and Arrhythmology Clinic, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ianni","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Cardiology Unit, Madonna del Soccorso Hospital, San Benedetto del Tronto, Marche, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Dello","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Cardiology and Arrhythmology Clinic, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito Maurizio","family":"Parato","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Cardiology Unit, Madonna del Soccorso Hospital, San Benedetto del Tronto, Marche, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Vagnarelli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Cardiology Unit, G.M. Lancisi Hospital, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"R1-20260831","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.jacc.2017.09.023","article-title":"Eosinophilic myocarditis: Characteristics, treatment, and outcomes","volume":"70","author":"Brambatti","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.iac.2007.07.001","article-title":"Cardiovascular manifestations of hypereosinophilic syndromes","volume":"27","author":"Ogbogu","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"R3-20260831","first-page":"18","article-title":"Cardiac involvement in eosinophilic granulomatosis with polyangiitis: A meta-analysis of 62 case reports","volume":"15","author":"Pakbaz","year":"2020","journal-title":"J Tehran Heart Cent"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/diagnostics16020184","article-title":"Unmasking the apex: Multimodality imaging for the evaluation of left ventricular apical obliteration","volume":"16","author":"Dentamaro","year":"2026","journal-title":"Diagnostics (Basel)"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"ytaf531","DOI":"10.1093\/ehjcr\/ytaf531","article-title":"The apex talks: Cardiac metastasis mimicking ST-segment elevation myocardial infarction","volume":"9","author":"Maurizi","year":"2025","journal-title":"Eur Heart J Case Rep"},{"key":"R6-20260831","first-page":"e4522","article-title":"A curious case of coronary vasospasm with cardiogenic shock: Type 1 kounis syndrome complicated by eosinophilic myocarditis","volume":"11","author":"Ravi","year":"2019","journal-title":"Cureus"},{"key":"R7-20260831","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4103\/jcecho.jcecho_125_20","article-title":"Eosinophilic myocarditis: Is endomyocardial biopsy essential for diagnosis in the era of advanced cardiac imaging?","volume":"31","author":"Taskesen","year":"2021","journal-title":"J Cardiovasc Echogr"},{"key":"R8-20260831","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/CIRCULATIONAHA.125.074797","article-title":"Natural history of patients with histologically proven acute eosinophilic myocarditis","volume":"153","author":"Ammirati","year":"2026","journal-title":"Circulation"},{"key":"R9-20260831","doi-asserted-by":"crossref","first-page":"bcr2016218992","DOI":"10.1136\/bcr-2016-218992","article-title":"Therapeutic effect of anti-IL-5 on eosinophilic myocarditis with large pericardial effusion","volume":"2017","author":"Song","year":"2017","journal-title":"BMJ Case Rep"}],"container-title":["Journal of Cardiovascular Echography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_35_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:00:40Z","timestamp":1788181240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_35_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jcecho.jcecho_35_26","relation":{},"ISSN":["2211-4122","2347-193X"],"issn-type":[{"value":"2211-4122","type":"print"},{"value":"2347-193X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"2026-02-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}