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This case report describes a 74-year-old male with a history of bioprosthetic mitral valve replacement, presenting with acute heart failure and severe mitral stenosis initially presumed to be thrombosis. However, advanced histopathological and microbiological analysis of the explanted valve identified the underlying cause as early fungal bioprosthetic valve endocarditis caused by Rhizopus oryzae. The authors emphasize the importance of early recognition, multidisciplinary management, and advanced diagnostic tools to optimize the outcomes in such rare and fatal conditions.<\/jats:p>","DOI":"10.4103\/jcecho.jcecho_6_25","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:00:24Z","timestamp":1759294824000},"page":"277-279","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Cardiac Prosthetic Mucormicosis: Things Are Not Always What They Seem"],"prefix":"10.4103","volume":"35","author":[{"given":"Luis Garc\u00eda","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Cardiology Department, Virgin of Victory University Hospital, Malaga, Spain"},{"name":"Biomedical Research Institute of Malaga, BIONAND Platform, Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Piserra L\u00f3pez-Fern\u00e1ndez 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