{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:58Z","timestamp":1787775898880,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pressure and volume loads are vital components of every congenital heart disease. Numerous studies have concentrated on investigating myocardial remodeling under varying loading conditions in animal models. The objective of this study was to compare myocardial responses in lesions with volume overload, specifically ventricular septal defects (VSD), and lesions with pressure overload, such as coarctation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      For this purpose, three study groups have been involved: a VSD group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 19), a coarctation (CoA) group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20), and healthy age- and sex-matched controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 21). The severity of VSD has been measured by its size. In contrast, the severity of discrete CoA was quantified by the pressure gradient across the coarcted segment. The parasternal long axis assessed septal hypertrophy and left ventricular (LV) dilatation\u2013systolic myocardial LV velocities using tissue Doppler imaging. The global longitudinal strain was performed to assess LV function accurately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The CoA groups displayed significant septal hypertrophy compared to the other two study groups: IVSd (CoA: 8 \u00b1 1.6 vs. VSD 5.7 \u00b1 0.9). LV dilatation was more marked in the VSD group: LV end-diastolic dimension (CoA: 30 \u00b1 3 vs. 25 \u00b1 1.7). Systolic septal and mitral annular velocities were reduced in the CoA group and intriguingly exaggerated in the VSD group: Septal basal systolic myocardial velocity: (VSD: 9 \u00b1 2 vs. CoA: 5 \u00b1 1 vs. Controls: 7 \u00b1 0.8). Myocardial GLS was markedly reduced in the CoA group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Besides the well-known eccentric-concentric hypertrophy paradigm in volume-pressure loading of the myocardium, pressure load seems to reduce myocardial velocities and LV function to a greater extent than volume loading. This is putatively mediated via myosin class switching, reduced myofilament sensitivity to calcium, and disrupted mechanical\u2013electrical synchrony.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcecho.jcecho_72_24","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T02:53:39Z","timestamp":1746068019000},"page":"50-54","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Discrepancy in Myocardial Responses to Pressure Overload versus Volume Load Lesions"],"prefix":"10.4103","volume":"35","author":[{"given":"Antoine Fakhry","family":"AbdelMassih","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt"},{"name":"Department of Cardiac Sciences, Pediatric Cardiology Division, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma AlZahraa Mostafa","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Mouhareb","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourine","family":"Diab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, New Giza University, New Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Helmy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Nephrology Unit, Faculty of Medicine, Cairo University, Cairo, 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relaxation","volume":"7","author":"Chung","year":"2016","journal-title":"Front Physiol"},{"key":"R10-20260423","doi-asserted-by":"crossref","first-page":"e202213213.","DOI":"10.1085\/jgp.202213213","article-title":"Cardiac myosin filaments are directly regulated by calcium","volume":"154","author":"Ma","year":"2022","journal-title":"J Gen Physiol"},{"key":"R11-20260423","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/aps.2016.13","article-title":"Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model","volume":"37","author":"Huang","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"R12-20260423","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ejhf.465","article-title":"Molecular and structural transition mechanisms in long-term volume overload","volume":"18","author":"Mohamed","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"R13-20260423","first-page":"9","article-title":"Identification of early cardiac dysfunction and heterogeneity after pressure and volume overload in mice by high-frequency echocardiographic strain imaging","volume":"13","author":"Xu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"R14-20260423","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1007\/s00330-023-09595-z","article-title":"Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR","volume":"33","author":"Chen","year":"2023","journal-title":"Eur Radiol"},{"key":"R15-20260423","doi-asserted-by":"crossref","first-page":"3.","DOI":"10.1186\/s12947-019-0153-3","article-title":"The value of left ventricular strain-volume loops in predicting response to cardiac resynchronization therapy","volume":"17","author":"Zhu","year":"2019","journal-title":"Cardiovasc Ultrasound"}],"container-title":["Journal of 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