{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:00Z","timestamp":1786650000535,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Transcatheter mitral valve repair using the mitral transcatheter edge-to-edge repair (M-TEER) technique is a well-established therapeutic option for patients with severe mitral regurgitation. However, postprocedural complications can pose diagnostic and therapeutic challenges. We report the case of an 80-year-old woman with multiple comorbidities, including essential thrombocythemia, and a newly diagnosed bladder neoplasm, who recently underwent M-TEER. During routine follow-up, a mass was detected on the atrial surface of the mitral clip. The initial suspicion was thrombus. Transesophageal echocardiography confirmed a mass on the mitral clip. 18F-fluorodeoxyglucose positron emission tomography\/computed tomography showed focal uptake at the mitral valve level. Based on the modified Duke criteria and European Society of Cardiology 2023 guidelines, the diagnosis was considered \u201cpossible infective endocarditis.\u201d However, the concurrent neoplastic condition and lack of typical pathogens raised the alternative hypothesis of nonbacterial thrombotic endocarditis (NBTE). The patient was treated with intravenous anticoagulation and antibiotics. Serial imaging demonstrated a reduction in the size of the mass, but surgical intervention was precluded due to frailty. A definitive diagnosis could not be established.<\/jats:p>","DOI":"10.4103\/jcecho.jcecho_82_25","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T20:00:30Z","timestamp":1767124830000},"page":"416-419","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mitral Mass after Mitral Transcatheter Edge-to-edge Repair: Diagnostic Dilemma between Infective Endocarditis and Nonbacterial Thrombotic Endocarditis in a Patient with Malignancy"],"prefix":"10.4103","volume":"35","author":[{"given":"Giovanni","family":"Bellina","sequence":"first","affiliation":[{"name":"Niguarda \u201cDe Gasperis\u201d Cardio Center, ASST GOM Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Casadei","sequence":"additional","affiliation":[{"name":"Niguarda \u201cDe Gasperis\u201d Cardio Center, ASST GOM Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Musca","sequence":"additional","affiliation":[{"name":"Niguarda \u201cDe Gasperis\u201d Cardio Center, ASST GOM Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Maria","family":"Span\u00f2","sequence":"additional","affiliation":[{"name":"Niguarda \u201cDe Gasperis\u201d Cardio Center, ASST GOM Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Moreo","sequence":"additional","affiliation":[{"name":"Niguarda \u201cDe Gasperis\u201d Cardio Center, ASST GOM Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"R1-20251231","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"R2-20251231","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.1038\/s41598-022-12944-5","article-title":"Prevalence of left ventricular thrombus formation after mitral valve edge-to-edge repair","volume":"12","author":"Tichelb\u00e4cker","year":"2022","journal-title":"Sci Rep"},{"key":"R3-20251231","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s15010-023-02067-y","article-title":"Infective endocarditis involving MitraClip\u00a9 devices: A systematic literature review","volume":"51","author":"Bertolino","year":"2023","journal-title":"Infection"},{"key":"R4-20251231","first-page":"583","article-title":"Infective endocarditis following transcatheter edge-to-edge mitral valve repair: A systematic review","volume":"92","author":"Asmarats","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"R5-20251231","doi-asserted-by":"crossref","first-page":"810054","DOI":"10.3389\/fcvm.2021.810054","article-title":"Case Report: Living on the Edge-Transcatheter Mitral Valve Repair Related Infective Endocarditis","volume":"8","author":"Lewandowski","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"R6-20251231","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12872-018-0929-7","article-title":"Native valve endocarditis due to Escherichia coli infection: A case report and review of the literature","volume":"18","author":"Akuzawa","year":"2018","journal-title":"BMC Cardiovasc Disord"}],"container-title":["Journal of Cardiovascular Echography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_82_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:00:56Z","timestamp":1786647656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jcecho.jcecho_82_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jcecho.jcecho_82_25","relation":{},"ISSN":["2211-4122","2347-193X"],"issn-type":[{"value":"2211-4122","type":"print"},{"value":"2347-193X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-07-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}