{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:45:06Z","timestamp":1788608706827,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The major cause of re-intervention in Fallot patients (tetralogy of Fallot [TOF]) is pulmonary regurgitation. Current cutoffs for pulmonary valve replacement (PVR) are all cardiac magnetic resonance (CMR) derived, based on the regurgitant fraction (RF) and\/or right ventricular end-diastolic volume index. In this study, we aimed at determining if three-dimensional (3D)-derived right ventricular indices, notably RV global longitudinal strain (GLS), can act as a predictor for RF and hence facilitate the decision-making and timely referral of such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>For this purpose, 3D volumetry and speckle tracking echocardiography has been performed on Fallot patients, with recent CMR in the past 6 months, 42 controls were included to benchmark echocardiographic results. Echocardiography-derived left ventricle (LV) and right ventricle (RV) volumes as well as longitudinal strain were calculated and tested for diagnostic accuracy to predict RF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Bland\u2013Altmann analyses showed a good correlation between volumes obtained by CMR and those obtained by echocardiography, differences in volumes between CMR and echocardiography derived volumes were less evident in the LV compared to the RV, RV GLS &lt;11% was sensitive and specific in predicting severe pulmonary regurge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study of strains, particularly RV strains in repaired TOF patients, is not new to the literature. However, to our knowledge, previous studies did not attempt to determine a cutoff of RV GLS in predicting severe PR and subsequent need for PVR, the findings of this study are limited by a small sample size, but they open new horizons in the diagnostics of repaired TOF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jcecho.jcecho_84_24","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:00:20Z","timestamp":1753948820000},"page":"116-120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Predicting Regurgitant Fraction in Pediatric Patients with Repaired Fallot Using Right Ventricular Strain"],"prefix":"10.4103","volume":"35","author":[{"given":"Antoine Fakhry","family":"AbdelMassih","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt"},{"name":"Department of Cardiac Sciences, Pediatric Cardiology Division, SKMC, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"El-Sisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Abdel","family":"Hamid","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Division, Agouza Police Hospital, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baher M.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Bekheet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fped.2023.1098248","article-title":"The right ventricle in tetralogy of Fallot: Adaptation to sequential loading","volume":"11","author":"Alipour Symakani","year":"2023","journal-title":"Front Pediatr"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"e022694","DOI":"10.1161\/JAHA.121.022694","article-title":"Impact of right ventricular pressure load after repair of tetralogy of Fallot","volume":"11","author":"Latus","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00508-018-1330-3","article-title":"Echocardiographic evaluation of the right 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The quest continues","volume":"160","author":"DeCampli","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/echo.15486","article-title":"Evaluation of right ventricle systolic function after tetralogy of Fallot repair: A systematic review comparing cardiac magnetic resonance and global longitudinal strain","volume":"40","author":"Oliveira","year":"2023","journal-title":"Echocardiography"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12574-022-00593-6","article-title":"Right ventricular systolic strain in patients with pulmonary hypertension: Clinical feasibility, reproducibility, and correlation with ejection fraction","volume":"21","author":"Tunthong","year":"2023","journal-title":"J Echocardiogr"},{"key":"R15-20260421","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/echo.13302","article-title":"Right ventricular global longitudinal strain in repaired tetralogy of Fallot","volume":"33","author":"Toro","year":"2016","journal-title":"Echocardiography"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s10554-009-9477-7","article-title":"Right ventricular peak systolic longitudinal strain is a sensitive marker for right ventricular deterioration in adult patients with tetralogy of Fallot","volume":"25","author":"Scherptong","year":"2009","journal-title":"Int J Cardiovasc Imaging"},{"key":"R17-20260421","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/echo.12386","article-title":"Value of speckle tracking for the assessment of right ventricular function in patients operated on for tetralogy of Fallot. 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